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1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Structure
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- structure
CAS No.
345651-04-9
Chemical Name:
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-
Synonyms
BVDV IN-1;1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-;2-(4-(2-Phenylquinazolin-4-yl)piperazin-1-yl)ethanol;inhibit,virus,non-nucleoside,BVDV IN 1,activity,bovine,viral,antiviral,inhibitor,BVDVIN1,DNA/RNA Synthesis,diarrhea
CBNumber:
CB19310567
Molecular Formula:
C20H22N4O
Molecular Weight:
334.41
MDL Number:
MFCD10154938
MOL File:
345651-04-9.mol
Last updated:2024-07-02 08:55:01
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1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Properties

Boiling point 472.2±45.0 °C(Predicted)
Density 1?+-.0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 250 mg/mL (747.59 mM; Need ultrasonic)
form Solid
pka 14.96±0.10(Predicted)
color White to off-white

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Chemical Properties,Uses,Production

Biological Activity

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1]. BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp)[1].BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro[1].

References

[1]. Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4296 55
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9941 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 2882 58
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9459 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Zhengzhou convergence chemical co., LTD 58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Spectrum

1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-(345651-04-9)1HNMR
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- BVDV IN-1 inhibit,virus,non-nucleoside,BVDV IN 1,activity,bovine,viral,antiviral,inhibitor,BVDVIN1,DNA/RNA Synthesis,diarrhea 2-(4-(2-Phenylquinazolin-4-yl)piperazin-1-yl)ethanol 345651-04-9