ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) structure

CAS No.: 2310299-91-1

Chemical Name:: Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Synonyms: Gefapixant citrate;Gefapixant Citrat;Jifa Pisheng Citrate;methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

CBNumber:: CB19319045

Molecular Formula:: C20H27N5O11S

Molecular Weight:: 545.52

MDL Number:

MOL File:: 2310299-91-1.mol

Last updated:2025-04-18 09:51:46

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Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Properties

form	Solid
color	White to off-white
FDA UNII	DFK0FC2VVV

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Chemical Properties,Uses,Production

Uses

Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3].

in vivo

Gefapixant citrate (7d bid, orally) attenuates the weight bearing laterality with complete reversal of apparent hyperalgesia at the two higher doses in a rat model of knee osteoarthritis (14d following intra-articular administration of monoiodoacetate)^[2].

IC 50

P2X3 Receptor

References

[1] Anthony P. Ford, et al. The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Front Cell Neurosci. 2013; 7: 267. DOI:10.3389/fncel.2013.00267
[2] Ford AP, In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal. 2012 Feb;8(Suppl 1):3-26. DOI:10.1007/s11302-011-9271-6
[3] Martin Nguyen A, et al. Validation of a visual analog scale for assessing cough severity in patients with chronic cough. Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211049743. DOI:10.1177/17534666211049743

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Suppliers

Global( 29)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	485	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618501500038	3899766280@qq.com	China	26362	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	167	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19881	58
Wuhan Circle Star Chem-medical Technology Co.,Ltd	027-85558552 +undefined13437180835	Janel@circlestar-chem.com	China	999	58
Bayee Biotech (Anqing) Co., Ltd.	0556-5032306 18917961636	wtx@bayeebio.com	China	267	61
Hangzhou Kehui Pharmaceutical Co.,Ltd	0571-87359773 18094707759	sales10@hzkehuipharma.com	China	19	58
Taizhou Yuxin Biotechnology Co., Ltd.,	+86-0576--88902229 +86-13968687450	yuxin@yuxchem.com	China	218	58
Shenzhen Yaoyuan R&D Center Co., Ltd	13421666688 13421666688	664261110@qq.com	China	127	58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	028-83379370 13880556291	tcy@tcypharm.com	China	6294	58

Supplier	Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	58
TargetMol Chemicals Inc.	58
Wuhan Circle Star Chem-medical Technology Co.,Ltd	58
Bayee Biotech (Anqing) Co., Ltd.	61
Hangzhou Kehui Pharmaceutical Co.,Ltd	58
Taizhou Yuxin Biotechnology Co., Ltd.,	58
Shenzhen Yaoyuan R&D Center Co., Ltd	58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	58

View Lastest Price from Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-21	Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) 2310299-91-1	US $0.00-0.00 / kg	1kg	98	1000	Wuhan Circle Star Chem-medical Technology Co.,Ltd
2025-01-13	Gefapixant Citrate 2310299-91-1	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2025-01-13	Gefapixant Citrate. 2310299-91-1	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
2310299-91-1
US $0.00-0.00 / kg
98
Wuhan Circle Star Chem-medical Technology Co.,Ltd

Gefapixant Citrate
2310299-91-1
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Gefapixant Citrate.
2310299-91-1
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Gefapixant citrate methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Gefapixant Citrat Jifa Pisheng Citrate 2310299-91-1 C20H27N5O11S API