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Bemotrizinol

Bemotrizinol Structure
Bemotrizinol structure
CAS No.
187393-00-6
Chemical Name:
Bemotrizinol
Synonyms
BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE;uv-627;Tinosorb S Aqua;BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL;LGB-TS;CGF 1607;FAT 70'884;BEMOTRIZINOL;JADEWIN UV-S;Dsunpro Bemt
CBNumber:
CB1959495
Molecular Formula:
C38H49N3O5
Molecular Weight:
627.81
MDL Number:
MFCD08435974
MOL File:
187393-00-6.mol
Last updated:2024-08-21 22:41:43
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Bemotrizinol Properties

Melting point 83-85°; mp 80° (Mongiat)
Boiling point 782.0±70.0 °C(Predicted)
Density 1.109±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka 8.08±0.40(Predicted)
form Solid
color Light Yellow to Yellow
Odor Odorless
BRN 11322254
InChIKey SUKLKCPPDPQLNJ-UHFFFAOYSA-N
SMILES N1=C(C2=CC=C(OC)C=C2)N=C(C2=CC=C(OCC(CC)CCCC)C=C2O)N=C1C1=CC=C(OCC(CC)CCCC)C=C1O
LogP 7.647 (est)
FDA UNII PWZ1720CBH

SAFETY

Risk and Safety Statements

Hazard statements  H413
WGK Germany  3
HS Code  2933690000

Bemotrizinol price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 51825 Bemotrizinol analytical standard 187393-00-6 25mg $231 2024-03-01 Buy
Sigma-Aldrich 1048572 Bemotrizinol United States Pharmacopeia (USP) Reference Standard 187393-00-6 200mg $436 2024-03-01 Buy
TRC B131500 Bemotrizinol 187393-00-6 100mg $470 2021-12-16 Buy
AK Scientific 1943EM Bemotrizinol 187393-00-6 10g $667 2021-12-16 Buy
Biosynth Carbosynth FB161854 Bemotrizinol 187393-00-6 100g $300 2021-12-16 Buy
Product number Packaging Price Buy
51825 25mg $231 Buy
1048572 200mg $436 Buy
B131500 100mg $470 Buy
1943EM 10g $667 Buy
FB161854 100g $300 Buy

Bemotrizinol Chemical Properties,Uses,Production

Description

Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays. Compared to older broad-spectrum chemical agents, bemotrizinol is more more fat soluble (oil soluble in cosmetic oils) to aid in efficacy and broad-spectrum activity. It is claimed to be photostable, which increases its onset of action and its efficiency in providing protection against UV-rays upon topical application. Bemotrizinol is commonly marketed as Tinosorb S and Escalol S.

Uses

Bemotrizinol is a broad-spectrum UV absorber, absorbing both UVA and UVB. Bemotrizinol is added to various sunscreens to absorb UV rays.

Definition

ChEBI: Bemotrizinol is a member of methoxybenzenes.
The INCI name of Bemotrizinol is bis-ethylhexyloxyphenol methoxyphenyl triazine

brand name

Tinosorb S (Ciba Specialty Chemicals).

Flammability and Explosibility

Non flammable

Safety

Because bemotrizinol is relatively new to the sunscreen market there are few reports or studies available documenting its adverse effects and long term use. Studies to date have shown it to have a good safety profile. It is not significantly absorbed into the skin and rarely causes skin irritation. Unlike some other organic sunscreen agents, in vitro studies show that bemotrizinol does not appear to have hormonal effects. Further long-term human safety studies are required.

Synthesis

In a three-necked flask equipped with a stirrer, a thermometer and a condenser, 40.30 g (0.1 mol) of 2,4-bis(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazine, 29.02 g (0.21 mol) of potassium carbonate and 105 mL of N, N-dimethylformamide were added in sequence, and the temperature was raised to 100°C. Reflux and stir for 30 minutes; add 46.35g (0.24mol) of DMF solution containing isooctane bromide at a uniform rate within 1 hour, continue to reflux and stir at 100°C after the addition is complete, and monitor the reaction progress with a thin layer chromatography; after the reaction of the raw materials is completed, stop stirring, cool to room temperature, filter, add ethyl acetate to the filtrate for extraction, wash with saturated brine, dry the organic phase with anhydrous sodium sulfate, filter, and spin-dry the filtrate to obtain a colourless transparent oil, i.e. 50.4g of a crude product of bis-ethylhexyloxyphenol methoxyphenyl triazine (Bemotrizinol), with a yield of 80.2% and a purity of 89.90% detected by HPLC.

Advantages

The bis-ethylhexyloxyphenol methoxyphenyl triazine (Bemotrizinol) is a triazine ultraviolet absorbent, has efficient absorption in ultraviolet bands of UVA (320-400 nm) and UVB (280-320), has high molecular weight, is not easy to be absorbed by skin, has strong stability, and is widely applied to personal care and cosmetic products.

Regulations

Bemotrizinol is approved for use in Europe and Australasia. It is marketed under the brand names Tinosorb S and Escalol S. It is currently awaiting FDA approval so is not available in the USA.

Bemotrizinol synthesis

100-66-3
187393-00-6
Synthesis of Bemotrizinol from Anisole

Bemotrizinol Preparation Products And Raw materials

Raw materials

Preparation Products

Bemotrizinol Suppliers

Global( 301)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9257 58
Qingdao Truelight functional Material Technology Co., Ltd.
+86-13573844393 songjames@truelightchem.com China 221 58
airuikechemical co., ltd.
+undefined86-15315557071 sales06@airuikechemical.com China 983 58
ZhenYiBio Technology Inc
+8615309206328 alexxue@zhenyibio.com China 298 58
Watson Biotechnology Co.,Ltd
+86-18186686046 +86-18186686046 sales01@watsonbiotech.cn China 5853 58
Wuhan Fortuna Chemical Co.,Ltd
+8618007136271 hk@fortunachem.com China 5827 58
Qingdao Dexin Chemical Co., Ltd
+86-15553333686 +86-15553333686 15553333686@qq.com China 2865 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2967 58
Hebei Yime New Material Technology Co., Ltd. 		+86-66697723 +86-17703311139 admin@china-yime.com China 563 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 info@fortunachem.com China 5989 58
Supplier Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		58
Qingdao Truelight functional Material Technology Co., Ltd.
58
airuikechemical co., ltd.
58
ZhenYiBio Technology Inc
58
Watson Biotechnology Co.,Ltd
58
Wuhan Fortuna Chemical Co.,Ltd
58
Qingdao Dexin Chemical Co., Ltd
58
Jinan Finer Chemical Co., Ltd 		58
Hebei Yime New Material Technology Co., Ltd. 		58
Wuhan Fortuna Chemical Co., Ltd 		58

Related articles

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  • Bis-ethylhexyloxyphenol methoxyphenyl triazine, Product name also known as Tinosorb S, is a new type of broad-spectrum sunscre....
  • Jan 9，2020

View Lastest Price from Bemotrizinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bemotrizinol pictures 2024-08-24 Bemotrizinol
187393-00-6
 US $0.00-0.00 / kg 1kg 99% 20MT Watson Biotechnology Co.,Ltd
Bemotrizinol pictures 2024-08-23 Bemotrizinol
187393-00-6
 US $12.00 / KG 1KG 99% 500mt Jinan Finer Chemical Co., Ltd
Bis-ethylhexyloxyphenol methoxyphenyl triazine（BEMT） pictures 2024-08-22 Bis-ethylhexyloxyphenol methoxyphenyl triazine（BEMT）
187393-00-6
 US $0.00-0.00 / Kg/Bag 1Kg/Bag 99% up, High Density 20 tons Sinoway Industrial co., ltd.
  • Bemotrizinol pictures
  • Bemotrizinol
    187393-00-6
  • US $0.00-0.00 / kg
  • 99%
  • Watson Biotechnology Co.,Ltd
  • Bemotrizinol pictures
  • Bemotrizinol
    187393-00-6
  • US $12.00 / KG
  • 99%
  • Jinan Finer Chemical Co., Ltd

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2,2′-[6-(4-Methoxyphenyl)- 1,3,5-triazine-2,4-diyl] bis{5-[(2-ethylhexyl)oxy]phenol} CGF 1607 FAT 70'884 6,6'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-(2-ethylhexyloxy)phenol) 2,4-Bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (6Z)-3-(2-Ethylhexoxy)-6-[(4Z)-4-[4-(2-ethylhexoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-6-(4-methoxyphenyl)-1H-1,3,5-triazin-2-ylidene]cyclohexa-2,4-dien-1-one Phenol, 2,2-6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diylbis5-(2-ethylhexyl)oxy- BISETHYLHEXYLOXYPHENOLMETHOXYPHENOLTRIAZINE Bemotrizinol (200 mg) BEMOTRIZINOL LGB-TS Bemotrizinol/Bis Ethyl Hexyl Oxyphenolmethoxyphenyl Triazine 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydrody]-phenyl}-6-(4-methoxyphenyl)-(1,3,5)-triazine Tinosorb S Bemotrizinol uv absorber UV-S IS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE Diethyl hexoxyphenol methoxyphenyl triazine Bis-ethylhexyloxyphenol methoxyphenyl triazine Solution in Methanol/THF/Water, 1000μg/mL UV ABSORBER TRUELICHT UV S Bis-ethylhexyloxyphenol methoxyphenyl triazine（BEMT） JADEWIN UV-S JADEWIN UV 627 Tinosorb S Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine CAS 187393-00-6 Tinosorb S BEMT Bemotrizinol (1048572) Tinosorb S Aqua BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE uv-627 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL Bemotrizinol(Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine)/BEMT Bemotrizinol / UV S Bi-ethylhexoxyphenol methoxyphenyltriquine Bi-ethylhexoxyphenol methoxyphenyltriazine 2-HYDROXYETHYLUREA 2078-71-9 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (TINOSARB) Dsunpro Bemt Bemotrizinol(Tinosorb S) 6,6'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylhexyl)oxy)phenol) BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (TINOSORB) Bemotrizinol/Bis-Ethylhexyloxyphenol 6,6'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylheptyl)oxy)phenol) Piraxostat Impurity 15 6,6'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylheptyl)oxy)phenol) （TS） 187393-00-6 C38H49N3O5