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JNJ-42253432

JNJ-42253432 Structure
JNJ-42253432 structure
CAS No.
1428327-35-8
Chemical Name:
JNJ-42253432
Synonyms
JNJ-42253432;JNJ42253432,JNJ 42253432;5-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-2-methyl-N-[[1-(4-phenyl-1-piperazinyl)cyclohexyl]methyl]-
CBNumber:
CB19624176
Molecular Formula:
C28H38N4O
Molecular Weight:
446.63
MDL Number:
MOL File:
1428327-35-8.mol
Last updated:2024-07-02 08:55:01
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JNJ-42253432 Properties

Boiling point 592.8±50.0 °C(Predicted)
Density 1.130±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 16.14±0.20(Predicted)
form Solid
color White to off-white

JNJ-42253432 Chemical Properties,Uses,Production

Biological Activity

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1]. When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy[1].

References

[1]. Brian Lord, et al. Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41.

JNJ-42253432 Preparation Products And Raw materials

Raw materials

Preparation Products

JNJ-42253432 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Block Chemical Technology (Shanghai) Co., Ltd. 021-20432219 13918097649 li_jinfei@acblock-lab.com China 9962 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9268 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Block Chemical Technology (Shanghai) Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58

JNJ-42253432 Spectrum

JNJ-42253432(1428327-35-8)1HNMR
JNJ-42253432 JNJ42253432,JNJ 42253432 5-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-2-methyl-N-[[1-(4-phenyl-1-piperazinyl)cyclohexyl]methyl]- 1428327-35-8