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CAY10784
- CAS No.
- 1245814-52-1
- Chemical Name:
- CAY10784
- Synonyms
- CAY10784;STAT3-IN-17;CAY10784,CAY-10784;N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide;Benzamide, N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-
- CBNumber:
- CB19739401
- Molecular Formula:
- C11H6F3N3O3S
- Molecular Weight:
- 317.24
- MDL Number:
- MOL File:
- 1245814-52-1.mol
Last updated:2024-07-02 08:55:01
CAY10784 Chemical Properties,Uses,Production
Biological Activity
CAY10784 is a STAT3 inhibitor (IC50 = 0.74 μM in a reporter assay) and a derivative of WP1066 .1 It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 μM, respectively).2
References
1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitorsACS Med. Chem. Lett.(2021) 2.Ballard, T.E., Wang, X., Olekhnovich, I., et al.Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activityChemMedChem6(2)362-377(2011)
CAY10784 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10784 Suppliers
Global( 8)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 2882 | 58 |
ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1061 | 58 |
CAY10784
CAY10784,CAY-10784
Benzamide, N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-
N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide
STAT3-IN-17
1245814-52-1