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Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- structure

CAS No.: 1268490-12-5

Chemical Name:: Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-

Synonyms: GSK329;T24109;GSK-329;GSK 329;Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-;diarylurea,cardiac-specific kinase,cardioprotective outcomes,inhibit,Inhibitor,GSK329,ischemia/reperfusion,TNNI3K

CBNumber:: CB19816180

Molecular Formula:: C19H14Cl2F3N5O2

Molecular Weight:: 472.25

MDL Number:

MOL File:: 1268490-12-5.mol

Last updated:2024-07-02 08:55:01

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Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Properties

Boiling point	471.0±45.0 °C(Predicted)
Density	1.554±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (529.38 mM; Need ultrasonic)
pka	12.00±0.70(Predicted)
form	Solid
color	White to off-white

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Chemical Properties,Uses,Production

Biological Activity

GSK329 is a potent and selective diarylurea inhibitor of the cardiac-specific kinase TNNI3K. GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury[1].

storage

Store at -20°C

References

[1]. Patterson JR, et, al. Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf. J Med Chem. 2021 Nov 11;64(21):15651-15670.

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4252	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9887	58
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	chaolaichem@foxmail.com	China	8514	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	507	58
Shanghai Dongyang Biotechnology Co., Ltd.	0512-0512-13601744364 13601744364	chemsharker@126.com	China	893	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Absin Bioscience Inc.	021-38015121 15000105423	chenjw@absin.cn	China	24734	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
Shanghai Dongyang Biotechnology Co., Ltd.	58
DC Chemicals	58
Absin Bioscience Inc.	58

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Spectrum

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-(1268490-12-5)¹HNMR

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- GSK 329 GSK329 GSK-329 T24109 diarylurea,cardiac-specific kinase,cardioprotective outcomes,inhibit,Inhibitor,GSK329,ischemia/reperfusion,TNNI3K 1268490-12-5