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Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester

Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester structure

CAS No.: 1439366-88-7

Chemical Name:: Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester

Synonyms: ARN 077 (enantiomer);Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester

CBNumber:: CB19827867

Molecular Formula:: C16H21NO4

Molecular Weight:: 291.34

MDL Number:

MOL File:: 1439366-88-7.mol

Last updated:2024-07-02 08:55:01

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Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester Properties

Boiling point	474.4±44.0 °C(Predicted)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	10.45±0.40(Predicted)
color	White to off-white

Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester Chemical Properties,Uses,Production

Biological Activity

ARN 077 enantiomer (19) is the less active enantiomer of ARN 077, with an IC50 of 3.53 μM for rat NAAA[1].

References

[1]. Stefano Ponzano, et al. Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2013 Sep 12;56(17):6917-34.

Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester Preparation Products And Raw materials

Raw materials

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Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester ARN 077 (enantiomer) 1439366-88-7