ChemicalBook >> CAS DataBase List >>Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)-

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)-

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- structure

CAS No.: 2519537-69-8

Chemical Name:: Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)-

Synonyms: Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)-

CBNumber:: CB210602876

Molecular Formula:: C23H16F2N4O3

Molecular Weight:: 434.39

MDL Number:

MOL File:: 2519537-69-8.mol

Last updated:2023-03-31 09:12:57

Request For Quotation

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- Properties

Boiling point	743.4±60.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
pka	3.43±0.36(Predicted)

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- Chemical Properties,Uses,Production

Description

HOIPIN-8 is a novel potent and selective inhibitor of linear ubiquitin chain assembly complex (LUBAC). HOIPIN-?8 suppressed the linear ubiquitination activity by recombinant LUBAC at an IC50 value of 11 nM, corresponding to a 255-?fold increase over that of HOIPIN-?1. Furthermore, as compared with HOIPIN-?1, HOIPIN-?8 showed 10-?fold and 4-?fold enhanced inhibitory activities on LUBAC- and TNF-?α-?induced NF-?κB activation respectively, without cytotoxicity. These results indicated that HOIPIN-?8 is a powerful tool to explore the physiological functions of LUBAC.

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	cb5@aikonchem.com	China	10529	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58

Benzoic acid, 2-[3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxo-1-propen-1-yl]-4-(1-methyl-1H-pyrazol-4-yl)- 2519537-69-8 C23H16F2N4O3