4-Ethylphenol | 123-07-9

4-Ethylphenol Properties

Melting point	40-42 °C(lit.)
Boiling point	218-219 °C(lit.)
Density	1,011 g/cm³
vapor density	4.2 (vs air)
vapor pressure	0.13 mm Hg ( 20 °C)
refractive index	1.5330
FEMA	3156 \| P-ETHYLPHENOL
Flash point	213 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	4.9g/l
form	Crystalline Mass or Crystals
pka	pK1:10.0 (25°C)
Specific Gravity	1.0123 (20℃)
color	White to brownish
Odor	at 1.00 % in dipropylene glycol. phenolic castoreum smoke guaiacol
Odor Type	smoky
Water Solubility	4.9 g/L (25 ºC)
JECFA Number	694
BRN	1363317
Stability	Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.
InChIKey	HXDOZKJGKXYMEW-UHFFFAOYSA-N
LogP	2.1 at 20℃ and pH7
Surface tension	54mN/m at 998g/L and 22℃
Substances Added to Food (formerly EAFUS)	P-ETHYLPHENOL
CAS DataBase Reference	123-07-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	AGG7E6G0ZC
NIST Chemistry Reference	Phenol, 4-ethyl-(123-07-9)
EPA Substance Registry System	p-Ethylphenol (123-07-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Xi,C

Risk Statements

36/37/38-R36/37/38-34

Safety Statements

26-36-S36-S26-45-36/37/39

RIDADR

UN 2430 8/PG 3

WGK Germany

3

RTECS

SL4040000

TSCA

Yes

HazardClass

8

PackingGroup

III

HS Code

29071900

NFPA 704

	1
		0

4-Ethylphenol price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W315605	4-Ethylphenol ≥98%, FG	123-07-9	1kg	$245	2024-03-01	Buy
Sigma-Aldrich	W315605	4-Ethylphenol ≥98%, FG	123-07-9	10Kg	$1940	2024-03-01	Buy
Sigma-Aldrich	04700	4-Ethylphenol ≥97.0% (GC)	123-07-9	50g	$41.1	2024-03-01	Buy
Sigma-Aldrich	04700	4-Ethylphenol ≥97.0% (GC)	123-07-9	1kg	$193	2023-06-20	Buy
TCI Chemical	E0159	4-Ethylphenol >97.0%(GC)	123-07-9	25g	$23	2024-03-01	Buy

Product number	Packaging	Price	Buy
W315605	1kg	$245	Buy
W315605	10Kg	$1940	Buy
04700	50g	$41.1	Buy
04700	1kg	$193	Buy
E0159	25g	$23	Buy

4-Ethylphenol Chemical Properties,Uses,Production

Description

4-Ethylphenol (4-EP) is a phenolic compound with the formula C8H10O. It is colorless or white needles with a powerful woody-phenolic and yet somewhat sweet odor and tends to be yellow on exposure to light. It is slightly solouble in water, solouble in alcohol, ether and benzene and carbon disulfide. It is found in arabica coffee and can be produced in wine and beer by the spoilage yeast Brettanomyces. It is the starting material for the production of 4-vinylphenol and of various antioxidants and can also be used as an intermediate for pharmaceuticals and dyes. It is an industrially versatile commodity chemical widely applied in the pharmaceutical and food industries.

Chemical Properties

4-Ethylphenol, also known as p-Ethylphenol, is a colorless or white crystalline compound. It can turn yellow when exposed to light. It has a powerful woody-phenolic, medicinal, yet somewhat sweet odor. Its melting point is 4143℃, boiling point is 218219°C, and flash point is 100°C. It has a relative density of 1.011 and a refractive index of 1.5239. It is slightly soluble in water and soluble in ethanol, ether, acetone, benzene, and carbon disulfide. It is a natural component found in foods such as egg fruit, European sour cranberry, pork, rum, whisky, and coffee.

Occurrence

Reported found in yellow passion fruit, smoked fish, lean fish, beer, cognac, rum, whiskey, cider, sherry, grape wines and coffee

Uses

4-Ethylphenol is suitable for use in the determination of 4-ethylguaiacol and 4-ethylphenol in the aroma of red wines using headspace-solid-phase microextraction method. It is a chemical reagent used in the synthesis of 5-HT1A receptor agonists endowed with antinociceptive activity in vivo. It is also used in the preparation of isopropylamides as potent and noncovalent proteosome inhibitors.

Preparation

4-Ethylphenol is prpared by catalytic reaction between phenol and ethylene or ethanol; by heating 8-chloro-3-ethylbenzene with NaOH in the presence of copper powder.

Definition

ChEBI: 4-ethylphenol is a member of the class of phenols carrying an ethyl substituent at position 4. It has a role as a fungal xenobiotic metabolite.

Production Methods

4-Ethylphenol is produced industrially by sulfonation of ethylbenzene under mild (kinetically controlled) conditions and subsequent alkali fusion of the 4-ethylbenzenesulfonic acid obtained. The purity of the commercial product is 98%.

Aroma threshold values

Detection: 42 to 130 ppb

Synthesis Reference(s)

The Journal of Organic Chemistry, 14, p. 1089, 1949 DOI: 10.1021/jo01158a018

General Description

4-Ethylphenol is a volatile phenol. It has been synthesized from p-coumaric acid by employing a synthetic medium containing Dekkera bruxellensis ISA 1791. It has been identified as an aroma compound in red wine.

Hazard

Toxic material.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.

Toxicology

4-Ethylphenol is a potentially toxic compound, capable of producing respiratory distress, cardiovascular collapse, shock, ventricular tachycardia, and coma in an adult. Liver, lung, central nervous system and renal injury may also occur. In case of exposure to eyes, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Monitor for respiratory distress in case of inhalation exposure. Systemic manifestations of toxicity may include nausea, vomiting, diarrhea, dyspnea, tachypnea, pallor, and profuse sweating.

Purification Methods

Non-acidic impurities are removed by passing steam through a boiling solution containing 1 mole of the phenol and 1.75 moles of NaOH (as an aqueous 10% solution). The residue is cooled and acidified with 30% (v/v) H2SO4, and the free phenol is extracted into diethyl ether. The extract is washed with water, dried with CaSO4 and the ether is evaporated. The phenol is distilled at 100mm pressure through a Stedman gauze-packed column (p 11). It is further purified by fractional crystallisation by partial freezing, and by zone refining, under N2 [Biddiscombe et al. J Chem Soc 5764 1963]. Alternatively purify it via the benzoate, as for phenol. The 4-nitrophenylbenzoate has m 80o (from EtOH). [Beilstein 6 H 470, 6 III 1663, 5 IV 3020.]

References

[1] https://en.wikipedia.org/wiki/4-Ethylphenol
[2] http://www.hmdb.ca/metabolites/HMDB29306
[3] https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~x8ypqu:1:cpp
[4] https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~x8ypqu:1:manf
[5] YING ZHANG Shaojun D Liangkun Long. Heterologous synthesis of 4-ethylphenol in engineered Escherichia coli[J]. Process Biochemistry, 2020, 96: Pages 157-164. DOI:10.1016/j.procbio.2020.06.003.
[6] WOHLFARTH C. Dielectric constant of 4-ethylphenol[C]. 1900: 0. DOI:10.1007/978-3-540-75506-7\_257.
[7] K H JONES D J H P W Trudgill. 4-Ethylphenol metabolism by Aspergillus fumigatus.[J]. Applied and Environmental Microbiology, 1994, 60 6: 1978-1983. DOI:10.1128/aem.60.6.1978-1983.1994.

4-Ethylphenol Preparation Products And Raw materials

Raw materials

Copper Ethylbenzene Phenol, 2,6-dimethoxy-4-propyl- 2,6-Dimethoxyphenol Phenol, 4-ethyl-2,6-dimethoxy-

Preparation Products

pesticide emulsifier 603^<#^> pesticide emulsifier 601^<#^> emulsifier 12^<#^> pesticide emulsifier 602^<#^> p-Cresol

5-ETHYL-2-METHOXY-BENZENESULFONYL CHLORIDE Benzene, 1-(2-bromoethoxy)-4-ethyl- 4-ETHYLPHENYL 4-ETHYLBENZENECARBOXYLATE

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4-Ethylphenol Suppliers

Global( 424)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
NANJING PASTEUR ChEMICAL CO.,LTD	+86-18066069912 +86-18066069912	1390310770@qq.com	China	18	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5892	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20286	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
JINING XINHE CHEMICAL CO., LTD	+8615318402391	sales@xinhepharma.com	China	809	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55

Supplier	Advantage
NANJING PASTEUR ChEMICAL CO.,LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
JINING XINHE CHEMICAL CO., LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from 4-Ethylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	4-Ethylphenol 123-07-9	US $10.00 / KG	1KG	99%	100MT/year	Speranza Chemical Co., Ltd.
2024-11-19	4-Ethylphenol 123-07-9	US $29.00 / mL			10g	TargetMol Chemicals Inc.
2024-10-15	4-Ethylphenol 123-07-9	US $0.00-0.00 / Kg	1Kg	99.9%	200tons	airuikechemical co., ltd.

4-Ethylphenol
123-07-9
US $10.00 / KG
99%
Speranza Chemical Co., Ltd.

4-Ethylphenol
123-07-9
US $29.00 / mL
TargetMol Chemicals Inc.

4-Ethylphenol
123-07-9
US $0.00-0.00 / Kg
99.9%
airuikechemical co., ltd.

4-Ethylphenol Spectrum

4-Ethylphenol(123-07-9)MS 4-Ethylphenol(123-07-9)¹HNMR 4-Ethylphenol(123-07-9)¹³CNMR 4-Ethylphenol(123-07-9)IR1 4-Ethylphenol(123-07-9)IR2 4-Ethylphenol(123-07-9)IR3 4-Ethylphenol(123-07-9)IR 4-Ethylphenol(123-07-9)Raman

123-07-9(4-Ethylphenol)Related Search:

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