Herbacetin
- CAS No.
- 527-95-7
- Chemical Name:
- Herbacetin
- Synonyms
- Herbacetin-RM;Isoarticulatidin;HERBACETIN(P)(PLEASE CALL);Herbacetin,inhibit,Inhibitor;4',5,7,8-Tetrahydroxyflavonol;3,4',5,7,8-pentahydroxyflavone;Herbacetin 8-Hydroxykaempferol;Herbacetin, 98%, from Rhodiola rosea L.;3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
- CBNumber:
- CB21074417
- Molecular Formula:
- C15H10O7
- Molecular Weight:
- 302.24
- MDL Number:
- MFCD00210585
- MOL File:
- 527-95-7.mol
| Melting point | 284℃ |
|---|---|
| Boiling point | 618.7±55.0 °C(Predicted) |
| Density | 1.799 |
| solubility |
DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM) DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM) |
| form | A crystalline solid |
| pka | 6.49±0.40(Predicted) |
| color | Light yellow to yellow |
| LogP | 1.140 (est) |
| FDA UNII | 736854V2KE |
Herbacetin price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19285 | Herbacetin ≥98% | 527-95-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19285 | Herbacetin ≥98% | 527-95-7 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19285 | Herbacetin ≥98% | 527-95-7 | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 19285 | Herbacetin ≥98% | 527-95-7 | 25mg | $397 | 2024-03-01 | Buy |
| TRC | H235130 | Herbacetin | 527-95-7 | 1mg | $55 | 2021-12-16 | Buy |
Herbacetin Chemical Properties,Uses,Production
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
Uses
Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
Definition
ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
Biological Activity
Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
in vivo
Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity.
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Herbacetin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from Herbacetin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Herbacetin
527-95-7
|
US $39.00-147.00 / mg | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Herbacetin
527-95-7
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 100 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-07-25 | Herbacetin
527-95-7
|
US $0.00 / mg | 20mg | HPLC>99% | 1.5g | Jiangsu Yongjian Pharmaceutical Co.,Ltd |
-
- Herbacetin
527-95-7
- US $39.00-147.00 / mg
- 99.51%
- TargetMol Chemicals Inc.
-
- Herbacetin
527-95-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Herbacetin
527-95-7
- US $0.00 / mg
- HPLC>99%
- Jiangsu Yongjian Pharmaceutical Co.,Ltd