DSM421
- CAS No.
- 2011769-21-2
- Chemical Name:
- DSM421
- Synonyms
- DSM421, 10 mM in DMSO
- CBNumber:
- CB211075233
- Molecular Formula:
- C14H11F5N6
- Molecular Weight:
- 358.28
- MDL Number:
- MOL File:
- 2011769-21-2.mol
DSM421 Chemical Properties,Uses,Production
Description
DSM421 is a dihydroorotate Dehydrogenase Inhibitor (DHODH) with Improved Drug-like Properties for Treatment and Prevention of Malaria. SM421 showed equal activity against both P. falciparum and P. vivax field isolates. DSM421 has the potential to be developed as a single-dose cure or once-weekly chemopreventative for both P. falciparum and P. vivax malaria, leading to its advancement as a preclinical development candidate.
Uses
DSM-421 is an orally active Dihydroorotate dehydrogenase inhibitor. DSM-421 has antiplasmodium activity[1].
in vivo
DSM-421 (0.1-30 mg/kg orally for 4 consecutive days) has strong antimalarial activity in a SCID mouse model of Plasmodium falciparum [1].
References
[1] Phillips MA, et al. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis. 2016 Dec 9;2(12):945-957. DOI:10.1021/acsinfecdis.6b00144
DSM421 Preparation Products And Raw materials
Raw materials
Preparation Products
DSM421 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 47255 | 58 |
