Buquineran
- CAS No.
- 59184-78-0
- Chemical Name:
- Buquineran
- Synonyms
- BDPU;UK-14275;Buquineran;6,7-Dimethoxy-4-[4-(3-butylureido)piperidino]quinazoline;1-Butyl-3-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]urea;N-Butyl-N'-[1-(6,7-dimethoxyquinazolin-4-yl)-4-piperidinyl]urea;Urea, N-butyl-N'-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-
- CBNumber:
- CB21116997
- Molecular Formula:
- C20H29N5O3
- Molecular Weight:
- 387.48
- MDL Number:
- MFCD00867622
- MOL File:
- 59184-78-0.mol
| FDA UNII | AWC1VMS3HC |
|---|
Buquineran Chemical Properties,Uses,Production
Originator
Buquineran,Pfizer Central Research
Manufacturing Process
4-Chloro-6,7-dimethoxyquinazoline (45.0 g), 4-(3-n-butylureido)piperidine
monhydrochloride (80.0 g) and triethylamine (140 ml) were refluxed in
ethanol (450 ml) for 1.25 h. The mixture was then concentrated in vacuo and
the resultant solid was stirred in water which was then basified to pH 11 with
5 N NaOH solution. The suspension was shaken with chloroform and the
organic layer was separated, dried (Na2CO3) and evaporated to dryness in
vacuo to give a yellow oily solid. Trituration with ether followed by
recrystallization from ethanol gave the product (37.0 g) with small traces of
impurities, wich were removed by running a chloroform solution of it down a
glass column packed with "Florisil" and eluting with 10% isopropanol in
chloroform.
After evaporation, appropriate fractions were bulked to give a pure 4-(4-[3-nbutylureido]
piperidino)-6,7-dimethoxyquinazoline, melting point 204-205°C
(21.0 g; recrystallized from ethanol).
Therapeutic Function
Coronary vasodilator
Buquineran Preparation Products And Raw materials
Raw materials
Preparation Products
Buquineran Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Leancare Ltd. | -- | enquiry@leancare.co.uk | United Kingdom | 6460 | 42 |
| Lanospharma Laboratories Co.,Ltd | -- | sales@lanospharma.com | China | 6343 | 56 |
| 2A PharmaChem USA | -- | sales@2apharmachem.com | United States | 6148 | 39 |
| 3B Scientific Corporation | -- | sales@3bsc.com | United States | 6744 | 47 |
| Supplier | Advantage |
|---|---|
| Leancare Ltd. | 42 |
| Lanospharma Laboratories Co.,Ltd | 56 |
| 2A PharmaChem USA | 39 |
| 3B Scientific Corporation | 47 |