L-Arginine-guanido-15N2HCl
- CAS No.
- 204633-92-1
- Chemical Name:
- L-Arginine-guanido-15N2HCl
- Synonyms
- L-Arginine-guanido-15N2Cl;L-Arginine-guanido-15N2HCl;L-Arginine-15N2hydrochloride;L-ARGININE:HCL MICROBIOLOGICAL/PYROGEN TESTED (GUANIDO-15N2,98%+)
- CBNumber:
- CB21121591
- Molecular Formula:
- H*N=CNH(*NH2)(CH2)3-CH(NH2)COOH旽Cl
- Molecular Weight:
- 0
- MDL Number:
- MFCD00144557
- MOL File:
- Mol file
L-Arginine-guanido-15N2HCl price More Price(1)
L-Arginine-guanido-15N2HCl Chemical Properties,Uses,Production
Biological Activity
L-Arginine-15N2 ((S)-(+)-Arginine-15N2) hydrochloride is the 15N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.[3]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.[4]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.
L-Arginine-guanido-15N2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
L-Arginine-guanido-15N2HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 18561885118 | market@tlwb.com.cn | China | 3946 | 58 |
| Reer Technology (Shanghai) Co., LTD | 021-64400900 15800436310 | bessey@reertech.com | China | 4113 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 19921389125 | tech@zzbioco.com | China | 12064 | 58 |