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RMC6236

RMC6236 Structure
RMC6236 structure
CAS No.
2765081-21-6
Chemical Name:
RMC6236
Synonyms
RMC6236;(Z)-N-(11-ethyl-12-(2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)-2-methylcyclopropane-1-carboxamide;N-[21-ethyl-20-[2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide , RMC-6236
CBNumber:
CB211845498
Molecular Formula:
C44H58N8O5S
Molecular Weight:
811.06
MDL Number:
MOL File:
2765081-21-6.mol
Last updated:2025-04-28 21:36:36
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RMC6236 Properties

Density 1.37±0.1 g/cm3(Predicted)
form Solid
pka 14.56±0.40(Predicted)
color White to off-white
InChIKey FVICRBSEYSHKFY-UHFFFAOYSA-N
SMILES C(N1C2=CC=C3C4=CSC(CC(C(=O)N5CCCC(N5)C(=O)OCC(C)(C)CC(C2=C3)=C1C1C=C(N2CCN(C)CC2)C=NC=1C(C)OC)NC(C1CC1C)=O)=N4)C

RMC6236 Chemical Properties,Uses,Production

Uses

RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors[1][2][3].

in vivo

RMC-6236 (3-25 mg/kg; p.o.; single dose) shows dose-dependent blood and tumor exposure in the Capan-2 xenograft tumor-bearing BALB/c nude mouse model, with tumor exposure approximately 3-7 times higher than that in blood and relatively slower elimination from tumors[1].
RMC-6236 (10-25 mg/kg; p.o.; once daily; 4 weeks) shows dose-dependent antitumor activity in a series of human tumor xenograft models harboring prevalent KRAS mutations (such as Capan-2, NCI-H441, HPAC, NCI-H358, etc.)[1].
RMC-6236 (25 mg/kg; p.o.; once daily) can arrest tumor growth when used alone in xenograft models of KRASG12C-mutant NCI-H2122 non-small cell lung cancer and KRASG12D-mutant GP2D colorectal cancer, and it can lead to significant tumor regression when combined with KO-2806[2].

IC 50

KRas G12D

References

[1] Jiang J, et al. Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov. 2024 Jun 3;14(6):994-1017. DOI:10.1158/2159-8290.CD-24-0027
[2] Patel H V, et al. The farnesyl transferase inhibitor KO-2806 re-sensitizes relapsing tumors to RAS inhibition. BioRxiv, 2024: 2024.12. 20.629824.
[3] Long SA, et al. Evaluation of KRAS inhibitor-directed therapies for pancreatic cancer treatment. Front Oncol. 2024 May 10;14:1402128. DOI:10.3389/fonc.2024.1402128

RMC6236 Preparation Products And Raw materials

Raw materials

Preparation Products

RMC6236 Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Circle Star Chem-medical Technology Co.,Ltd 		027-85558552 +undefined13437180835 Janel@circlestar-chem.com China 1000 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32239 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
Chengdu Feibo Pharm Technology Co., Ltd +86 028-84641798 15982321820 abby@arkpharm.com China 10922 58
Jurong Coupling Biotechnology Co., Ltd. 19231718652 278191416@qq.com China 490 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 10000 58
Changzhou Borl Biotechnology Co.,LTD 13606124132;13656121842 luyan0021@163.com China 219 58
Anqing Benro pharmachem Technology Co.,Ltd. 05565209906 15391842992 794263564@qq.com China 118 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2672 58
hubei PharmaStandard Co., Ltd. 027-19050701 13545374703 cbbspring@163.com China 408 58
Supplier Advantage
Wuhan Circle Star Chem-medical Technology Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Chengdu Feibo Pharm Technology Co., Ltd 58
Jurong Coupling Biotechnology Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Changzhou Borl Biotechnology Co.,LTD 58
Anqing Benro pharmachem Technology Co.,Ltd. 58
Shanghai Tachizaki Biomedical Research Center 58
hubei PharmaStandard Co., Ltd. 58

View Lastest Price from RMC6236 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RAS-IN-2 pictures 2025-04-29 RAS-IN-2
2765081-21-6
 US $0.00-0.00 / g 1g 98 1000 Wuhan Circle Star Chem-medical Technology Co.,Ltd
RMC-6236 pictures 2025-04-28 RMC-6236
2765081-21-6
 US $58.00-229.00 / mg 99.62% 10g TargetMol Chemicals Inc.
  • RAS-IN-2 pictures
  • RAS-IN-2
    2765081-21-6
  • US $0.00-0.00 / g
  • 98
  • Wuhan Circle Star Chem-medical Technology Co.,Ltd
  • RMC-6236 pictures
  • RMC-6236
    2765081-21-6
  • US $58.00-229.00 / mg
  • 99.62%
  • TargetMol Chemicals Inc.
RMC6236 N-[21-ethyl-20-[2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide (Z)-N-(11-ethyl-12-(2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)-2-methylcyclopropane-1-carboxamide (1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide , RMC-6236 (1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide 2765081-21-6