ChemicalBook >> CAS DataBase List >>2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- structure

CAS No.: 2573302-50-6

Chemical Name:: 2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

Synonyms: KTX-955;2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

CBNumber:: CB212245318

Molecular Formula:: C46H51F3N8O7

Molecular Weight:: 884.94

MDL Number:

MOL File:: 2573302-50-6.mol

Last updated:2025-04-17 18:22:24

Request For Quotation

2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- Properties

Density	1.53±0.1 g/cm3(Predicted)
pka	10.77±0.40(Predicted)

2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- Chemical Properties,Uses,Production

Uses

KTX-955 is an antumor and effective IRAK4 degrader, with DC50 values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively[1]. KTX-955 is composed of CRBN ligand (blue part) Pomalidomide (HY-10984) and target protein ligand (red part) IRAK4-IN-20 (HY-150735).

IC 50

IRAK4: 5 nM (IC₅₀)

References

[1] Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS).
[2] Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1

2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2573302-50-6(2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-)Related Search:

INDEX NAME NOT YET ASSIGNED 2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]methyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- INDEX NAME NOT YET ASSIGNED 2-Pyridinecarboxamide, N-[2-[trans-4-[[[3-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]propyl]methylamino]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-

2-Pyridinecarboxamide, 6-(1,1-difluoroethyl)-N-[2-[trans-4-[[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-methoxy-2H-indazol-5-yl]-

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