1,7-Diaminoheptane, N-amidino-
- CAS No.
- 150333-69-0
- Chemical Name:
- 1,7-Diaminoheptane, N-amidino-
- Synonyms
- 2-(7-aminoheptyl)guanidine;Guanidine, N-(7-aminoheptyl)-;1,7-Diaminoheptane, N-amidino-;N1-Guanyl-1,7-diaminoheptane (GC7)
- CBNumber:
- CB21238532
- Molecular Formula:
- C8H20N4
- Molecular Weight:
- 172.27
- MDL Number:
- MFCD31619261
- MOL File:
- 150333-69-0.mol
1,7-Diaminoheptane, N-amidino- price More Price(1)
1,7-Diaminoheptane, N-amidino- Chemical Properties,Uses,Production
Definition
ChEBI: Polyamine that can act as an inhibitor of deoxyhypusine synthase activity (GO:0034038).
General Description
A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 μM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 μM and 40 μM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 μM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 μM, with no apparent cytotoxicity. At 25 μM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
1,7-Diaminoheptane, N-amidino- Preparation Products And Raw materials
Raw materials
Preparation Products
1,7-Diaminoheptane, N-amidino- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |