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apogossypol

apogossypol structure

CAS No.: 66389-74-0

Chemical Name:: apogossypol

Synonyms: NSC736630;apogossypol;(+)-APOGOSSYPOL;APOGOSSYPOL;NSC736630;(+)Apogossypol,(+) Apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol

CBNumber:: CB21268526

Molecular Formula:: C28H30O6

Molecular Weight:: 462.53

MDL Number:

MOL File:: 66389-74-0.mol

Last updated:2024-10-23 13:36:13

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apogossypol Properties

Melting point	118-123 °C
Boiling point	673.3±50.0 °C(Predicted)
Density	1.335±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	>16.2mg/mL in DMSO with gentle warming
form	Powder
pka	8.03±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

apogossypol price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ApexBio Technology	B4902	(+)-Apogossypol	66389-74-0	5mg	$333	2021-12-16	Buy
ApexBio Technology	B4902	(+)-Apogossypol	66389-74-0	10mg	$475	2021-12-16	Buy
ApexBio Technology	B4902	(+)-Apogossypol	66389-74-0	10mM(in 1mL DMSO)	$490	2021-12-16	Buy
CSNpharm	CSN18376	(+)-Apogossypol	66389-74-0	5mg	$336	2021-12-16	Buy
Crysdot	CD31001130	(+)-Apogossypol 98+%	66389-74-0	10mg	$350	2021-12-16	Buy

Product number	Packaging	Price	Buy
B4902	5mg	$333	Buy
B4902	10mg	$475	Buy
B4902	10mM(in 1mL DMSO)	$490	Buy
CSN18376	5mg	$336	Buy
CD31001130	10mg	$350	Buy

apogossypol Chemical Properties,Uses,Production

Biological Activity

(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.

in vitro

In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K _d values of 1.7 μM.

in vivo

Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.

target

Mcl-1

< span> 2.6 μM (EC ₅₀ )

Bcl-2

2.8 μM (EC ₅₀ )

Bcl-xL

3.69 μM (EC ₅₀ )

apogossypol Preparation Products And Raw materials

Raw materials

Preparation Products

apogossypol Suppliers

Global( 21)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9245	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19885	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61
Nanjing Peiwill Biotechnology Co.,Ltd.	025-57027729 15850702895	15850702895@163.com	China	73	55
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12306	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4660	60
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9729	58
Absin Bioscience Inc.	021-38015121 15000105423	wulan@absin.cn	China	24731	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Henan Aochuang Chemical Co.,Ltd.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Chembest Research Laboratories Limited	61
Nanjing Peiwill Biotechnology Co.,Ltd.	55
Beijing Jin Ming Biotechnology Co., Ltd.	58
Musechem	60
Fan De(Beijing) Biotechnology Co., Ltd.	58
Absin Bioscience Inc.	58

View Lastest Price from apogossypol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	(+)-Apogossypol 66389-74-0	US $3100.00-2380.00 / mg			10g	TargetMol Chemicals Inc.
	2022-09-23	apogossypol 66389-74-0	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

(+)-Apogossypol
66389-74-0
US $3100.00-2380.00 / mg
TargetMol Chemicals Inc.

apogossypol
66389-74-0
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

apogossypol Spectrum

apogossypol(66389-74-0)MS

apogossypol (+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol NSC736630 APOGOSSYPOL;NSC736630 3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol (+)-APOGOSSYPOL [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)- (+)Apogossypol,(+) Apogossypol 66389-74-0