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Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)-

Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- structure

CAS No.: 2226732-62-1

Chemical Name:: Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)-

Synonyms: CVN636;Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)-

CBNumber:: CB213151708

Molecular Formula:: C19H20FNO4S

Molecular Weight:: 377.43

MDL Number:

MOL File:: 2226732-62-1.mol

Last updated:2025-04-18 09:51:50

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Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- Properties

Boiling point	629.6±55.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
form	Solid
pka	13.48±0.40(Predicted)
color	White to off-white

Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- Chemical Properties,Uses,Production

Uses

CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1].

in vivo

CVN636 (0.3-3 mg/kg; p.o.) reduces ethanol self-administration in msP rats^[1].

Animal Model:	msP rat^[1]
Dosage:	0.3, 1, and 3 mg/kg
Administration:	oral administration
Result:	Reduced alcohol self-administration in a dose-dependent.

IC 50

hu mGluR7: 7 nM (EC₅₀)

References

[1] Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. DOI:10.1021/acsmedchemlett.2c00529
[2] Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. DOI:10.1021/acsmedchemlett.2c00529

Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	998	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19727	58

Supplier	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- CVN636 2226732-62-1