3,9-bis((ethylthio)methyl)-K-252a
- CAS No.
- 156177-65-0
- Chemical Name:
- 3,9-bis((ethylthio)methyl)-K-252a
- Synonyms
- Kt7515;C106592;Cep1347;Kt-7515;Kt 7515;Cep-1347;Cep 1347;9-Bis(etsm)-K-252a;CEP-1347 (KT-7515;3,9-Bis(etsm)-K-252a
- CBNumber:
- CB21381603
- Molecular Formula:
- C33H33N3O5S2
- Molecular Weight:
- 615.76
- MDL Number:
- MFCD27991285
- MOL File:
- 156177-65-0.mol
- MSDS File:
- SDS
| Boiling point | 786.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | <6.16mg/ml in DMSO |
| form | solid |
| pka | 11.94±0.40(Predicted) |
| color | Pale yellow |
| FDA UNII | 200HA2LIMK |
3,9-bis((ethylthio)methyl)-K-252a price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4924 | CEP1347 ≥97%(HPLC) | 156177-65-0 | 1 | $288 | 2021-12-16 | Buy |
| TRC | C256695 | CEP1347 | 156177-65-0 | 0.5mg | $450 | 2021-12-16 | Buy |
| Usbiological | 254917 | CEP 1347 | 156177-65-0 | 1mg | $603 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000067 | CEP-1347 95.00% | 156177-65-0 | 5MG | $495.73 | 2021-12-16 | Buy |
| ApexBio Technology | B7720 | CEP1347 | 156177-65-0 | 1mg | $417 | 2021-12-16 | Buy |
3,9-bis((ethylthio)methyl)-K-252a Chemical Properties,Uses,Production
Uses
CEP 1347 (cas# 156177-65-0) is a useful research chemical.CEP 1347 promotes neuronal survival in culture and in vivo.
Biological Activity
cep-1347, also called kt 7515, is an inhibitor of the c-jun n-terminal kinase (jnk) signaling pathway, with an ic50 value for jnk1 activation of 20 ± 2 nm in rat embryonic motoneurons [1].the jnk pathway, also known as the stress-activated protein kinase (sapk) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. jnk activation by phosphorylation is important for neuronal cell death after injury in vivo and after trophic factor withdrawal in vitro [2].cep-1347 induced neuronal survival. jnk1 activity in untreated cell cultures increased approximately fourfold within 24 hr after plating. as early as 15 min after the application of cep-1347 at 500 nm, the activity of jnk1 sharply decreased to ~50% of control levels. for the next 24 hr, the activity of jnk1 continued to decrease. cultures rich in motoneurons were grown in the presence of cep-1347 at increasing concentrations, and the ic50 for jnk1 activity at 22 hr was 21 ± 2 nm, whereas the ec50 for cell survival at 5 d was 20 ± 2 nm [1].cep-1347 can affect noise-induced hearing loss. data showed that hearing thresholds 2 d before noise exposure showed no significant difference between the noise-exposed control and treated group. hearing threshold shifts in all guinea pigs 2 d after the noise exposure. by day 6 after exposure, threshold shifts were significantly less in the cep-1347 group than in the noise-exposed control group. by 2 weeks after exposure, the difference between the two groups became more pronounced [2].
storage
Store at -20°C
References
[1]. maroney ac, glicksman ma, basma an, et al. motoneuron apoptosis is blocked by cep-1347 (kt 7515), a novel inhibitor of the jnk signaling pathway[j]. the journal of neuroscience, 1998, 18(1): 104-111.
[2]. pirvola u, liang xq, virkkala j, et al. rescue of hearing, auditory hair cells, and neurons by cep-1347/kt7515, an inhibitor of c-jun n-terminal kinase activation[j]. the journal of neuroscience, 2000, 20(1): 43-50.
3,9-bis((ethylthio)methyl)-K-252a Preparation Products And Raw materials
Raw materials
Preparation Products
3,9-bis((ethylthio)methyl)-K-252a Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21675 | 55 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3617 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |