INGENOL-3-HEXANOATE
- CAS No.
- 83036-61-7
- Chemical Name:
- INGENOL-3-HEXANOATE
- Synonyms
- INGENOL-3-HEXANOATE;Ingenol 3 Hexanoate,Ingenol 3Hexanoate;Hexanoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
- CBNumber:
- CB21431142
- Molecular Formula:
- C26H38O6
- Molecular Weight:
- 446.58
- MDL Number:
- MOL File:
- 83036-61-7.mol
INGENOL-3-HEXANOATE Chemical Properties,Uses,Production
Description
Ingenol 3-Hexanoate novel potent reactivator of latent HIV-1.
in vitro
One of the sgRNAs (LTR5), which binds specifically in the HIV-1 LTR NFκB binding site, was able to promote robust repression of HIV-1 reactivation in latently infected T cells stimulated with Phorbol 12-Myristate 13-Acetate (PMA) and Ingenol B (IngB), both potent protein kinase C (PKC) stimulators._x000D_ _x000D_ Reference: Retrovirology. 2022 Jun 22;19(1):12. https://pubmed.ncbi.nlm.nih.gov/35733180/
in vivo
However, significant toxicity risks and the lack of evidence supporting their activity in vivo have limited further evaluation of PKC agonists as HIV latency-reversing agents (LRA) in cure strategies. Here this study evaluated whether GSK445A, a stabilized ingenol-B derivative, can induce HIV/simian immunodeficiency virus (SIV) transcription and virus production in vitro and demonstrate pharmacological activity in nonhuman primates (NHP). In vivo, GSK445A tolerability was established in SIV-na?ve RM at 15 μg/kg although tolerability was reduced in SIV-infected RM on ART. Increases in plasma viremia following GSK445A administration were suggestive of increased SIV transcription in vivo. Collectively, these results indicate that GSK445A is a potent HIV/SIV LRA in vitro and has a tolerable safety profile amenable for further evaluation in vivo in NHP models of HIV cure/remission._x000D_ _x000D_ Reference: PLoS Pathog. 2022 Jan 18;18(1):e1010245. https://pubmed.ncbi.nlm.nih.gov/35041707/
target
Ingenol 3-Hexanoate, or Ingenol B, is a novel potent reactivator of latent HIV-1.
INGENOL-3-HEXANOATE Preparation Products And Raw materials
Raw materials
Preparation Products
INGENOL-3-HEXANOATE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Beijing Biocreative Technology Co., Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |