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piperlonguminine

piperlonguminine structure

CAS No.: 5950-12-9

Chemical Name:: piperlonguminine

Synonyms: MEXE;mexedrone;Piperlonguminin;Piperlonguminine;N-Isobutylpiperamide;Mexedrone MEXE MDPHP BK-2CB;Mexedrone Cas no.: 5950-12-9 White crystal 99%;5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide;(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide;5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide

CBNumber:: CB21562460

Molecular Formula:: C16H19NO3

Molecular Weight:: 273.33

MDL Number:: MFCD15146947

MOL File:: 5950-12-9.mol

Last updated:2024-10-11 11:19:41

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piperlonguminine Properties

Melting point	l66-8°C
storage temp.	Store at -20°C
solubility	≤3mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form	crystalline solid
color	White to off-white
FDA UNII	HN39MC8KIO

piperlonguminine price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	9001155	Piperlonguminine ≥98%	5950-12-9	5mg	$48	2024-03-01	Buy
Cayman Chemical	9001155	Piperlonguminine ≥98%	5950-12-9	10mg	$62	2024-03-01	Buy
Cayman Chemical	9001155	Piperlonguminine ≥98%	5950-12-9	25mg	$117	2024-03-01	Buy
Cayman Chemical	9001155	Piperlonguminine ≥98%	5950-12-9	50mg	$210	2024-03-01	Buy
ApexBio Technology	C3508	Piperlonguminine	5950-12-9	50mg	$222	2021-12-16	Buy

Product number	Packaging	Price	Buy
9001155	5mg	$48	Buy
9001155	10mg	$62	Buy
9001155	25mg	$117	Buy
9001155	50mg	$210	Buy
C3508	50mg	$222	Buy

piperlonguminine Chemical Properties,Uses,Production

Description

Piperlonguminine is an alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties. Piperlonguminine (3-12.5 μM) has been shown to dose dependently decrease expression of amyloid precursor protein and amyloid-β peptide in human neuroblastoma cells, suggesting it may have implication in treating Alzheimer’s disease.

Description

This amide alkaloid also occurs in the roots of Piper longum and yields colourless needles from EtOH. The ultraviolet spectrum exhibits absorption maxima at 245,256, 307 and 340 mil. The side chain is doubly unsaturated and on catalytic hydrogenation, the base furnishes the tetrahydro derivative, m.p. 66°C.

Definition

ChEBI: (E,E)-Piperlonguminine is a member of benzodioxoles.

Biological Activity

Piperlonguminine is an alkaloid amide isolated from the Piper species. It has a wide range of biological properties including anti-inflammatory, anti-tumour, neuroprotective, anti-platelet, anti-melanogenic, anti-fungal and antibacterial activities. In addition, its derivative piperlonguminine acid has Antihyperlipidemic activity.

in vitro

in a previous study, piperlonguminine was discovered to inhibit melanin production in melanoma b16 cells stimulated with α-msh, 3-isobutyl-1-methylxanthine or protoporphyrin ix, where piperlonguminine showed stronger depigmenting efficacy. however, piperlonguminine could not alter1-oleoyl-2-acetyl-sn-glycerol-induced melanogenesis and could not affect protein kinase c-mediated melanin production. in additioin, piperlonguminine was not able to inhibit the catalytic activity of cell-free tyrosinase from melanoma b16 cells, and such effect was attributed to the inhibitory action of piperlonguminine on α-msh-induced signaling via camp to the camp responsive element binding protein [1].

in vivo

in vivo, rats were subjected to middle cerebral artery occlusion for 1h, followed by reperfusion for 23 h. the results showed that the intraperitoneal injection of piperlonguminine pe at 2.4 mg/kg was able to produce a significant neuroprotective potential in rats with cerebral ischemia. in addition, piperlonguminine could attenuate the neurological deficit scores, brain infarct volume and brain water content, and could inhibit the activation of nf-κb and mapk [2].

References

Chatterjee, Dutta., Tetrahedron Lett., 1797 (1966)
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

piperlonguminine synthesis

Synthesis of piperlonguminine from Isobutylamine and 2,4-Pentadienoyl chloride, 5-(1,3-benzodioxol-5-yl)-

piperlonguminine Preparation Products And Raw materials

Raw materials

2,4-Pentadienoyl chloride, 5-(1,3-benzodioxol-5-yl)- 5-(3,4-METHYLENEDIOXYPHENYL)-2,4-PENTADIENOIC ACID Isobutylamine

Preparation Products

piperlonguminine Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Yongjian Pharmaceutical Co.,Ltd	+86-0523-80183620 +86-17701422015	982552664@qq.com	China	258	58
Hebei Dangtong Import and export Co LTD	+86-13910575315 +86-13910575315	admin@hbdangtong.com	China	1000	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hebei Bonster Technology Co.,Limited	+8613315996897	bsterltd.wendy@gmail.com	China	792	58
Hebei Runbin Biotechnology Co. LTD	13180553332	2179877681@qq.com	CHINA	990	58
Wuhan Monad Medicine Tech Co.,LTD	02768782018 18771942761	sales01@whmonad.com	CHINA	979	58
Hebei Zhanyao Biotechnology Co. Ltd	15369953316 +8615369953316	admin@zhanyaobio.com	China	2123	58

Supplier	Advantage
Jiangsu Yongjian Pharmaceutical Co.,Ltd	58
Hebei Dangtong Import and export Co LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Bonster Technology Co.,Limited	58
Hebei Runbin Biotechnology Co. LTD	58
Wuhan Monad Medicine Tech Co.,LTD	58
Hebei Zhanyao Biotechnology Co. Ltd	58

View Lastest Price from piperlonguminine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-10-24	piperlonguminine 5950-12-9	US $24.00-20.00 / kg	1kg	99%	300tons	Hebei Dangtong Import and export Co LTD
2024-01-08	Piperlonguminine 5950-12-9	US $9.00 / KG	1KG	99%	50000tons	Wuhan Boyuan Import & Export Co., LTD
2023-08-16	Piperlonguminine 5950-12-9	US $170.00 / KG	1KG	>99%	50000kg/Month	Weijer International Trade (Hebei) Co., Ltd

piperlonguminine
5950-12-9
US $24.00-20.00 / kg
99%
Hebei Dangtong Import and export Co LTD

Piperlonguminine
5950-12-9
US $9.00 / KG
99%
Wuhan Boyuan Import & Export Co., LTD

Piperlonguminine
5950-12-9
US $170.00 / KG
>99%
Weijer International Trade (Hebei) Co., Ltd

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MEXE 5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide mexedrone N-Isobutylpiperamide (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide Piperlonguminine Mexedrone MEXE MDPHP BK-2CB Mexedrone Cas no.: 5950-12-9 White crystal 99% Mexedrone Crystal , mexe Pharmaceutical Intermediates CAS 5950-12-9 2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)- TIANFU-CHEM CAS:5950-12-9 5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide Piperlonguminin amide,Inhibitor,inhibit,alkaloid,anti-melanogenic,Bacterial,antibacterial,neuroprotective,antifungal,Piperlonguminine,anti-platelet,Fungal,antitumor,anti-inflammatory,Piper (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-N-isobutylpenta-2,4-dienamide 5950-12-9 5650-12-9 for pharmaceutical intermediate