ZONISAMIDE-13C2-15N
- CAS No.
- 1188265-58-8
- Chemical Name:
- ZONISAMIDE-13C2-15N
- Synonyms
- ZONISAMIDE-13C2-15N;13C2,15N]-Zonisamide
- CBNumber:
- CB2156257
- Molecular Formula:
- C8H8N2O3S
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD08063551
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H360 | |||||||||
| Precautionary statements | P201-P202-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501 | |||||||||
| NFPA 704 |
|
ZONISAMIDE-13C2-15N price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28807 | Zonisamide-13C2,15N | 1188265-58-8 | 1mg | $396 | 2024-03-01 | Buy |
| TRC | Z700003 | Zonisamide-13C2-15N | 1188265-58-8 | 10mg | $1980 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | CN17154 | Zonisamide-13C2,15N | 1188265-58-8 | 5mg | $2900 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | CN100165 | Zonisamid2-15C2-15N | 1188265-58-8 | 1mg | $475 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | CN17154 | Zonisamide-13C2,15N | 1188265-58-8 | 1mg | $1750 | 2021-12-16 | Buy |
ZONISAMIDE-13C2-15N Chemical Properties,Uses,Production
Description
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent. It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml. In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current. Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively. In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid (HVA; ) or dihydroxyphenyl acetic acid (DOPAC; ), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson''s disease. Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.
Uses
Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.
ZONISAMIDE-13C2-15N Preparation Products And Raw materials
Raw materials
Preparation Products
ZONISAMIDE-13C2-15N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94717 | 76 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1958 | 55 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9934 | 55 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 8228 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 9996 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 11572 | 58 |