ANTI-LAR
- CAS No.
- Chemical Name:
- ANTI-LAR
- Synonyms
- ANTI-LAR;Anti-PTPRF antibody produced in rabbit;Anti-Tyrosine-protein phosphatase receptor type F;Anti-Leukocyte antigen-related tyrosine phosphatase;Anti-PTPRF (C-terminal) antibody produced in rabbit;Anti-Leukocyte common antigen-related tyrosine phosphatase
- CBNumber:
- CB2161321
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01633591
- MOL File:
- Mol file
ANTI-LAR price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4200321 | Anti-PTPRF (C-terminal) antibody produced in rabbit IgG fraction of antiserum | 200μL | $518 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA012710 | Anti-PTPRF antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $580 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA012710 | Anti-PTPRF antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy | |
| American Custom Chemicals Corporation | ATB0014742 | ANTI-LAR 95.00% | 5MG | $498.15 | 2021-12-16 | Buy |
ANTI-LAR Chemical Properties,Uses,Production
Uses
Anti-PTPRF antibody is suitable for use in immunoblot (1:250-1:500 using lysates of HEK-293T cells over-expressing human PTPRF).
General Description
PTPRF removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function .
Biological Activity
Tyrosine-protein phosphatase receptor type F (PTPRF) inhibits the epithelial cell migration by preventing phosphorylation and hence the increase in the free pool of β-catenin, controlling its signaling functions. It regulates epithelial cell-cell contacts and maintains epithelial integrity at adherens junctions. The loss of function of PTPRF leads to malignant progression and metastasis. It has been shown to bind to liprin-α (SYD2) and take part in axon guidance. PTPRF also contributes to mammary gland development. In vitro, it binds to the intracellular LAR-interacting protein at the discrete ends of focal adhesion. Hence, it also has a role in regulating cell-matrix interactions.
ANTI-LAR Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-LAR Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
| Supplier | Advantage |
|---|---|
| Merck KGaA | 58 |