6-Iodo-1H-indazole
- CAS No.
- 261953-36-0
- Chemical Name:
- 6-Iodo-1H-indazole
- Synonyms
- 6-IODOINDAZOLE;6-IodoindazoL;6-iodo-1h1indazole;6-IODO (1H)INDAZOLE;1H-Indazole, 6-iodo-;Axitinib Intermediate 3;6-IODO (1H)INDAZOLE ISO 9001:2015 REACH
- CBNumber:
- CB2178484
- Molecular Formula:
- C7H5IN2
- Molecular Weight:
- 244.03
- MDL Number:
- MFCD04114695
- MOL File:
- 261953-36-0.mol
- MSDS File:
- SDS
Melting point | 207.0 to 211.0 °C |
---|---|
Boiling point | 358.2±15.0 °C(Predicted) |
Density | 2.082±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 12.96±0.40(Predicted) |
form | Liquid |
color | Clear colorless to light yellow |
InChI | InChI=1S/C7H5IN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10) |
InChIKey | RSGAXJZKQDNFEP-UHFFFAOYSA-N |
SMILES | N1C2=C(C=CC(I)=C2)C=N1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
HS Code | 29339980 | |||||||||
NFPA 704 |
|
6-Iodo-1H-indazole price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | I0933 | 6-Iodoindazole >98.0%(GC) | 261953-36-0 | 1g | $168 | 2024-03-01 | Buy |
TCI Chemical | I0933 | 6-Iodoindazole >98.0%(GC) | 261953-36-0 | 5g | $584 | 2024-03-01 | Buy |
TRC | I707370 | 6-Iodo-1H-indazole | 261953-36-0 | 250mg | $140 | 2021-12-16 | Buy |
Matrix Scientific | 068734 | 6-Iodoindazole 95+% | 261953-36-0 | 1g | $98 | 2021-12-16 | Buy |
Matrix Scientific | 068734 | 6-Iodoindazole 95+% | 261953-36-0 | 5g | $337 | 2021-12-16 | Buy |
6-Iodo-1H-indazole Chemical Properties,Uses,Production
Physical Form
Light yellow to Brown powder to crystal
Uses
6-Iodo-1H-indazole is an intermediate used to synthesize inhibitors of Chk1.
Synthesis Reference(s)
[1] NOOLVI M N, PATEL H M. Small Molecule Tyrosine Kinase Inhibitors: The New Dawn for Cancer Therapy[J]. Letters in Drug Design & Discovery, 1900, 9(1): 84-125. DOI:10.2174/157018012798192892.
Synthesis
Revill P. and co-worker synthesized Axitinib by
iodination of 6-iodo-1H-indazole (100) to give 3,6-di iodo-
1H-indazole (101) ,which on further reaction with 2-
mercapto-N-methylbenzenesulfinamide gives 2-(3-iodo-1Hindazol-6-ylthio)-N-methylbenzamide (101), the same can be
obtained via 2-(1H-indazol-6-ylthion)-N-methylbenzamide
(102) starting from 6-iodo-1H-indazole (100) through
alternative route. N-protection of 2-(3-iodo-1H-indazol-6-
ylthio)-N-methylbenzamide (101) by Boc2, DMAP or DHP,
TsOH gives respective N-protected intermediates 103, 104.
Further treatment of 103, 104 with 2-vinyl pyridine give rise
to N-protected-2-(1-methyl-3-(2-(pyridine-2-yl) vinyl)-1Hindazole-6-ylthio) benzothioamide 105 and 106. Deprotection of 105 and 106 gives destination compound
axitinib (107), the same can be obtained without protection
from 2-(3-iodo-1H-indazol-6-ylthio)-N-methylbenzamide
(101) by simple reaction with 2-vinyl pyridine[1].
6-Iodo-1H-indazole Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 57 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12490 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 207 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1139 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21665 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
View Lastest Price from 6-Iodo-1H-indazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-27 | 6-Iodo-1H-indazole
261953-36-0
|
US $1.00-0.50 / kg | 1kg | 99% | 200 | Jinan Million Pharmaceutical Co., Ltd | ||
2024-09-23 | 6-Iodo-1H-indazole
261953-36-0
|
US $0.00-0.00 / kg | 1kg | ≥98% by HPLC | 100kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. | ||
2024-08-20 | 6-Iodo-1H-indazole
261953-36-0
|
US $10.00-7.00 / kg | 1kg | 99.9% | 20ton | Hebei Ganmiao New material Technology Co., LTD |
- 6-Iodo-1H-indazole
261953-36-0
- US $1.00-0.50 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
- 6-Iodo-1H-indazole
261953-36-0
- US $0.00-0.00 / kg
- ≥98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
- 6-Iodo-1H-indazole
261953-36-0
- US $10.00-7.00 / kg
- 99.9%
- Hebei Ganmiao New material Technology Co., LTD
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