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W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE Structure
W-7 HYDROCHLORIDE structure
CAS No.
61714-27-0
Chemical Name:
W-7 HYDROCHLORIDE
Synonyms
W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
CBNumber:
CB2182197
Molecular Formula:
C16H22Cl2N2O2S
Molecular Weight:
377.33
MDL Number:
MFCD00012559
MOL File:
61714-27-0.mol
Last updated:2024-11-18 21:14:07
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W-7 HYDROCHLORIDE Properties

Melting point 220-222 °C
storage temp. -20°C
solubility methanol: 25 mg/mL, clear, colorless
form Off-white crystalline solid
color White to Off-White
BRN 6030174
CAS DataBase Reference 61714-27-0(CAS DataBase Reference)
EWG's Food Scores 1

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
RTECS  QK0786000
F  3-10
HS Code  2935909099

W-7 HYDROCHLORIDE price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A3281 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride 61714-27-0 25mg $156 2024-03-01 Buy
Sigma-Aldrich 681629 W-7, Hydrochloride 61714-27-0 10mg $144 2024-03-01 Buy
TCI Chemical A2409 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride 61714-27-0 100MG $180 2024-03-01 Buy
TCI Chemical A2409 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride 61714-27-0 1G $647 2024-03-01 Buy
Cayman Chemical 14826 W-7 (hydrochloride) ≥98% 61714-27-0 10mg $57 2024-03-01 Buy
Product number Packaging Price Buy
A3281 25mg $156 Buy
681629 10mg $144 Buy
A2409 100MG $180 Buy
A2409 1G $647 Buy
14826 10mg $57 Buy

W-7 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).

Chemical Properties

White Crystalline Solid

Uses

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.

Uses

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

General Description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).

Biological Activity

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at RT

W-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

W-7 HYDROCHLORIDE Suppliers

Global( 131)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30240 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49978 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Compound Net Biotechnology Inc. 		+8615303909093 sales@compound-net.com China 2914 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58
Compound Net Biotechnology Inc. 		58
Amadis Chemical Company Limited 		58
Mainchem Co., Ltd. 55

View Lastest Price from W-7 HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
W-7 hydrochloride pictures 2024-11-18 W-7 hydrochloride
61714-27-0
 US $30.00-64.00 / mg 99.63% 10g TargetMol Chemicals Inc.

W-7 HYDROCHLORIDE Spectrum

W-7 HYDROCHLORIDE(61714-27-0)IRW-7 HYDROCHLORIDE(61714-27-0)Raman

61714-27-0(W-7 HYDROCHLORIDE)Related Search:

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OMEGA-7 HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE W-7 W-7 HYDROCHLORIDE N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7 ulfonaMide W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem CS-1064 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride > SKL179 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor 61714-27-0 C16H21ClN2O2SClH Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators Calcium signaling