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N-(p-Aminobenzoyl)glutamic acid

CAS No.
4271-30-1
Chemical Name:
N-(p-Aminobenzoyl)glutamic acid
Synonyms
N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID;Methotrexate EP Impurity K;(2S)-2-(4-Aminobenzamido)pentanedioic Acid;(2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid;NSC 71042;H-4-ABZ-GLU-OH;Folic acid iMpurity A;Methotrexate Impurity K;Folic Acid EP Impurity A;P-aminobenzoyl glutamate
CBNumber:
CB2193546
Molecular Formula:
C12H14N2O5
Molecular Weight:
266.25
MDL Number:
MFCD00042821
MOL File:
4271-30-1.mol
Last updated:2024-10-24 21:11:45

N-(p-Aminobenzoyl)glutamic acid Properties

Melting point ~175 °C (dec.)
alpha -15 º (c=2% in 0.1N HCl)
Boiling point 409.45°C (rough estimate)
Density 1.2846 (rough estimate)
refractive index 1.6660 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Aqueous Base (Sparingly), Aqueous Acid (Sparingly), DMSO (Sparingly)
form Solid
pka 3.50±0.10(Predicted)
color White to Light
Merck 14,426
BRN 2816320
Stability Hygroscopic
InChIKey GADGMZDHLQLZRI-VIFPVBQESA-N
CAS DataBase Reference 4271-30-1(CAS DataBase Reference)
FDA UNII 9BKY99A8HJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  2924296000

N-(p-Aminobenzoyl)glutamic acid price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0879 N-(4-Aminobenzoyl)-L-glutamic acid ≥98% (TLC) 4271-30-1 5g $470 2024-03-01 Buy
Sigma-Aldrich 1019870 N-(4-Aminobenzoyl)-L-glutamic acid United States Pharmacopeia (USP) Reference Standard 4271-30-1 50mg $436 2024-03-01 Buy
TCI Chemical A0442 N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T) 4271-30-1 1g $97 2024-03-01 Buy
TCI Chemical A0442 N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T) 4271-30-1 5g $315 2024-03-01 Buy
Sigma-Aldrich Y0001242 Folic acid impurity A European Pharmacopoeia (EP) Reference Standard 4271-30-1 y0001242 $220 2024-03-01 Buy
Product number Packaging Price Buy
A0879 5g $470 Buy
1019870 50mg $436 Buy
A0442 1g $97 Buy
A0442 5g $315 Buy
Y0001242 y0001242 $220 Buy

N-(p-Aminobenzoyl)glutamic acid Chemical Properties,Uses,Production

Chemical Properties

Light Tan Waxy Solid

Uses

Major metabolite of 5-Methyltetrahydrofolic Acid

Uses

Marker in folate metabolism studies.

Definition

ChEBI: A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.

Purification Methods

Crystallise the acid from H2O. Also purify it by dissolving 2.7g in H2O (130mL), adding aqueous NaOH to pH 5.5 and adding portionwise a solution of 0.5M CuSO4 to complete precipitation of the Cu salt. This salt is filtered off, suspended in H2O and H2S is bubbled through to precipitate CuS, filter, evaporate and recrystallise the residue from H2O. It has max (H2O) at 273nm. [Backer & Houtman Recl Trav Chim Pays-Bas 70 738, 743 1951, Beilstein 14 IV 1153.]

6758-40-3
4271-30-1
Synthesis of N-(p-Aminobenzoyl)glutamic acid from P-NITROBENZOYL-L-GLUTAMIC ACID

N-(p-Aminobenzoyl)glutamic acid Preparation Products And Raw materials

Global( 462)Suppliers
Supplier Tel Email Country ProdList Advantage
TAIZHOU DKD CHEMICAL CO., LTD.
+8618658336633 yf.chen@tzdkdchem.com China 134 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325 sales1@chuanghaibio.com China 5889 58
Changzhou Rokechem Technology Co., Ltd.
18758118018 sales001@rokechem.com China 255 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630 bess@weibangbio.com China 18151 58
airuikechemical co., ltd.
+86-18353166132 +86-18353166132 sales02@airuikechemical.com China 983 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 970 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902 angelia@hbmojin.com China 1176 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18751 58

View Lastest Price from N-(p-Aminobenzoyl)glutamic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(4-Aminobenzoyl)-L-glutamic acid pictures 2024-12-27 N-(4-Aminobenzoyl)-L-glutamic acid
4271-30-1
US $30.00 / kg 1kg 98% 2000kg hebei hongtan Biotechnology Co., Ltd
N-(4-Aminobenzoyl)-L-glutamic acid pictures 2024-12-26 N-(4-Aminobenzoyl)-L-glutamic acid
4271-30-1
US $0.00 / kg 1kg 98.5% 200mt/year Jinan Finer Chemical Co., Ltd
N-(4-aminobenzoyl)-L-glutamic acid pictures 2024-12-24 N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1
US $0.00-0.00 / g 1g 99.99% 20 tons airuikechemical co., ltd.

N-(p-Aminobenzoyl)glutamic acid Spectrum

N-(p-Aminobenzoyl)glutamic acid 2-[(4-aminobenzoyl)amino]glutaric acid 2-[(4-azanylphenyl)carbonylamino]pentanedioic acid 4-AMINOBENZOYLGLUTAMIC ACID 4-AMINOBENZOIC GLUTAMIC ACID 4-aminobenzoyl-L-glutamic acid NSC 71042 (S)-2-(4-AMinobenzaMido)pentanedioic acid Folic acid iMpurity A Folic acid iMpurity A N-(4-AMinobenzoyl)-L-glutaMic acid N-(P-Aminobenzoyl)-L-glutamic acidN-(P-Aminobenzoyl)-L-(+)glutamicacid EuE N-(4-aminobenzoyl)-L-Glutamic acid (Folic Acid Imp A) 4-Aminobenzoylglutamic Acid (50 mg) Methotrexate Impurity K H-4-ABZ-GLU-OH N-(P-AMINOBENZOYL)-L-GLUTAMIC ACID P-AMINOBENZOYL-L-GLUTAMIC ACID P-AMINO BENZAMIDE GLUTAMIC ACID N-(4-Aminobenzoyl)-L-Glutaminic Acid L-Glutamic acid, N-(4-aminobenzoyl)- Methotrexate Impurity 11(EP-K) (2S)-2-[(4-aminophenyl)formamido]pentanedioic acid Methotrexate Impurity K (Folinic Acid Impurity A) Calcium Levofolinate EP Impurity A Calcium Levofolinate Impurity 1(Calcium Levofolinate EP Impurity A) N-(4-carbamoyl)-L-glutamic acid Folinic Acid Impurity A (Methotrexate Impurity K) N-(4-Aminobenzoyl)-L-glutamic Acid > (2S)-2-[(4-Aminobenzoyl)amino]penta Folic acid impurity A CRS N-4-Aminobenzoyl-L-glutaminsure Folinic Acid Impurity A (4-Aminobenzoyl Glutamic Acid) Impurity A of Calcium Levofolinate Levofolinate EP Impurity A Folic Acid EP Impurity A Folic Acid Impurity 1(Folic Acid EP Impurity A) N-(4-aminobenzoyl)-L-glutamicaci N-p-aminobenzoyl-L-glutamic acid USP/EP/BP N-(p-Aminobenzoyl)glutamic acid USP/EP/BP Methotrexate Impurity 11(Methotrexate EP Impurity K) Para amino-benzoyl glutamate Methotrexate EP Impurity K (Folic Acid EP Impurity A) Folic Acid EP Impurity A (Methotrexate EP Impurity K) N-(4-Aminobenzoyl)-L-glutamic acid, ≥98% (TLC) 4-Aminobenzoylglutamic Acid (F0M031) Folic acid Impurity AQ: What is Folic acid Impurity A Q: What is the CAS Number of Folic acid Impurity A Q: What is the storage condition of Folic acid Impurity A 4-Aminobenzoylglutamic Acid (1019870) (2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid (2S)-2-(4-Aminobenzamido)pentanedioic Acid Methotrexate EP Impurity K N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID Methotrexate EP Impurity K (Folinic Acid EP Impurity A) N-(4-aminobenzoyl) -L-glutamate N-(p-Aminobenzoyl)glutamicaci Calcium Folinate EP Impurity A Folinic Acid Impurity A (Methotrexate EP Impurity K) Folic Acid Hydrate EP Impurity A Methotrexate EP Impurity K(Folic Acid EP Impurity A、Levofolinate EP Impurity A)