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H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2

CAS No.
111857-96-6
Chemical Name:
H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2
Synonyms
BIM 23042;BIM 23042 TFA;(D-2-Nal5,Cys6;BIM-23042, DC-13-217;H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2;(D-2-NAL5,CYS6·11,TYR7,D-TRP8,VAL10,2-NAL12)-SOMATOSTATIN;(D-2-NAL5,CYS6'11,TYR7,D-TRP8,VAL10,2-NAL12)-SOMATOSTATIN-14 (5-12) AMIDE;(D-2-Nal?,Cys?·??,Tyr?,D-Trp?,Val??,2-Nal??)-Somatostatin-14 (5-12) amide trifluoroacetate salt;L-Alaninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-3-(2-naphthalenyl)-, cyclic (2→7)-disulfide
CBNumber:
CB2221348
Molecular Formula:
C63H73N11O9S2
Molecular Weight:
1192.45
MDL Number:
MFCD00237258
MOL File:
111857-96-6.mol
Last updated:2023-05-18 11:31:02

H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 Properties

Boiling point 1554.2±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. -15°C
solubility Soluble to 1 mg/ml in 0.1% acetic acid
pka 9.90±0.15(Predicted)
form solid
color White

H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 254761 BIM 23042 111857-96-6 1mg $389 2021-12-16 Buy
American Custom Chemicals Corporation PEP0004454 BIM-23042 95.00% 111857-96-6 5MG $496.93 2021-12-16 Buy
ApexBio Technology B5401 BIM23042 111857-96-6 1mg $219 2021-12-16 Buy
Product number Packaging Price Buy
254761 1mg $389 Buy
PEP0004454 5MG $496.93 Buy
B5401 1mg $219 Buy

H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 Chemical Properties,Uses,Production

Biological Activity

ki: 49 ±14 nm for neuromedin b-induced endpoint in hunmbr cellsneuromedin b, a mammalian peptide of the bombesinlike peptide family sharing amino acid homology with its amphibian counterpart ranatensin, elicits a diverse array of biological responses in central and peripheral tissues. bim 23042 [d-nal-cys-tyr- d-trp-lys-val-cys-nal-nh2] is a selective neuromedin b antagonist.

in vitro

bim 23042 has a l00-fold greater affinity for bb1 receptors than bb2 receptors. the submaximal mobilisation observed with neuromedin b (1 nm) was abolished by bim 23042 but restored with a subsequently higher concentration of neuromedin b (1 μm). bim 23042 competitively inhibited neuromedin b-induced endpoint in hunmbr cells with a ki of 49 ±14 nm [1].

References

[1] ryan rr, taylor je, daniel jl, cowan a. pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin b receptors. eur j pharmacol. 1996 jun 13;306(1-3):307-14.

H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 Suppliers

Global( 44)Suppliers
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Shanghai Daken Advanced Materials Co.,Ltd
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View Lastest Price from H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 pictures 2022-10-12 H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2
111857-96-6
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2 (D-2-NAL5,CYS6'11,TYR7,D-TRP8,VAL10,2-NAL12)-SOMATOSTATIN-14 (5-12) AMIDE (D-2-Nal5,Cys6 BIM-23042, DC-13-217 BIM 23042 L-Alaninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-3-(2-naphthalenyl)-, cyclic (2→7)-disulfide (D-2-NAL5,CYS6·11,TYR7,D-TRP8,VAL10,2-NAL12)-SOMATOSTATIN (D-2-Nal?,Cys?·??,Tyr?,D-Trp?,Val??,2-Nal??)-Somatostatin-14 (5-12) amide trifluoroacetate salt BIM 23042 TFA 111857-96-6 C63H73N11O9S2 C62H73N11O9S2