SENEGENIN
- CAS No.
- 2469-34-3
- Chemical Name:
- SENEGENIN
- Synonyms
- SENEGIN;SENEGENIN;Tenuigenin;Tenuifgenin;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid;28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2
- CBNumber:
- CB2222527
- Molecular Formula:
- C30H45ClO6
- Molecular Weight:
- 537.13
- MDL Number:
- MFCD00466906
- MOL File:
- 2469-34-3.mol
- MSDS File:
- SDS
Melting point | 290-292℃ |
---|---|
alpha | D +19° (c = 0.70 in ethanol) |
Boiling point | 674.1±55.0 °C(Predicted) |
Density | 1.28 |
storage temp. | 2-8°C |
solubility | DMSO: soluble10mg/mL, clear |
pka | 4.27±0.70(Predicted) |
form | powder |
color | white to beige |
FDA UNII | 06S1QH951L |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P301+P312+P330 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | RC8815000 | |||||||||
Toxicity | LD50 intraperitoneal in mouse: 3mg/kg | |||||||||
NFPA 704 |
|
SENEGENIN price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 5mg | $96 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 25mg | $464 | 2023-06-20 | Buy |
Cayman Chemical | 28824 | Tenuigenin | 2469-34-3 | 5mg | $75 | 2024-03-01 | Buy |
Cayman Chemical | 28824 | Tenuigenin | 2469-34-3 | 100mg | $975 | 2024-03-01 | Buy |
Cayman Chemical | 28824 | Tenuigenin | 2469-34-3 | 10mg | $143 | 2024-03-01 | Buy |
SENEGENIN Chemical Properties,Uses,Production
Description
Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
Uses
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
Definition
ChEBI: Senegenin is a 12alpha-hydroxy steroid.
SENEGENIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
View Lastest Price from SENEGENIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-12 | SENEGENIN
2469-34-3
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
2023-02-24 | Senegenin
2469-34-3
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
2023-02-24 | Senegenin
2469-34-3
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |