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Proparacaine hydrochloride

CAS No.
5875-06-9
Chemical Name:
Proparacaine hydrochloride
Synonyms
alcaine;ophthain;keracaine;ophthetic;PROPARACAINE HCL;chibro-heracaine;Proparacaine HCI;Proparacaine HydrochL;ophthainehydrochloride;PROPARACAINE HYDROCHLORIDE
CBNumber:
CB2242028
Molecular Formula:
C16H27ClN2O3
Molecular Weight:
330.85
MDL Number:
MFCD00083467
MOL File:
5875-06-9.mol
MSDS File:
SDS
Last updated:2024-09-25 20:20:04

Proparacaine hydrochloride Properties

Melting point 182.0-183.3°
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol, Water
form Solid
pka 3.2(at 25℃)
color White to Off-White
λmax 300nm(MeOH)(lit.)
Merck 14,7807
InChI InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
InChIKey BFUUJUGQJUTPAF-UHFFFAOYSA-N
SMILES C(OCCN(CC)CC)(=O)C1=CC=C(OCCC)C(N)=C1.[H]Cl
CAS DataBase Reference 5875-06-9(CAS DataBase Reference)
FDA UNII U96OL57GOY

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H317-H319
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36-43
Safety Statements  26-36
WGK Germany  3
RTECS  DG3065000
HS Code  2922504500
NFPA 704
0
1 0

Proparacaine hydrochloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P2156 Proparacaine Hydrochloride >98.0%(HPLC)(T) 5875-06-9 1g $72 2024-03-01 Buy
TCI Chemical P2156 Proparacaine Hydrochloride >98.0%(HPLC)(T) 5875-06-9 5g $237 2024-03-01 Buy
TRC P761800 Proparacaine Hydrochloride 5875-06-9 500mg $275 2021-12-16 Buy
TRC P761800 Proparacaine Hydrochloride 5875-06-9 50mg $95 2021-12-16 Buy
American Custom Chemicals Corporation API0003948 PROPARACAINE HYDROCHLORIDE 95.00% 5875-06-9 10MG $721.88 2021-12-16 Buy
Product number Packaging Price Buy
P2156 1g $72 Buy
P2156 5g $237 Buy
P761800 500mg $275 Buy
P761800 50mg $95 Buy
API0003948 10MG $721.88 Buy

Proparacaine hydrochloride Chemical Properties,Uses,Production

Description

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Uses

Topical anesthetic (ophthalmic); Neuronal conductance inhibitor.

brand name

Alcaine (Alcon); Ophthetic (Allergan); Paracaine (Optopics).

Clinical Use

Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice.

Side effects

Occasional temporary stinging, burning and conjunctival redness may occur with the use of proparacaine. A rare, severe, immediate-type, apparently hyperallergic corneal reaction characterized by acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and sometimes iritis with descemetitis has been reported. Allergic contact dermatitis from proparacaine with drying and fissuring of the fingertips has been reported.

Mode of action

The mechanism of action of proparacaine hydrochloride is to reduce the instantaneous permeability of neurons to sodium, stabilize the nerve cell membrane, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia.Likely inhibits epithelial voltage gated sodium channels like other local anesthetics.

References

1. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. DOI:10.1016/j.jpba.2020.113497
2. https://pi.bausch.com/globalassets/pdf/PackageInserts/Pharma/Rx-Generics/Proparacaine-HCl-Ophthalmic-Solution.pdf
3. Imming P., Sinning C., Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct; 5(10):821-34. DOI:10.1038/nrd2132
4. T., Levent T., Inci M.A. Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. Int J Ophthalmol. 2015; 8(5): 938–944. DOI:10.3980/j.issn.2222-3959.2015.05.15
5. Proparacaine Hydrochloride Topical Drop and Intracameral 0.5% Lignocaine for Phacotrabeculectomy in Patients with Primary Open Angle Glaucoma DOI:10.4103/0974-9233.134669
6. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=447a2a64-0507-4fe8-bb44-cc36c3916151&type=display

Proparacaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 202)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316 admin@zhanyaobio.com China 2123 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920 sales@chembj.net China 289 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12840 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325 sales1@chuanghaibio.com China 5893 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315 admin@hbdangtong.com China 1000 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039 admin@firsky-cn.com China 427 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907 qinhe02@xaltbio.com China 997 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 615 58
Sigma Audley
+86-15937194204 +86-18126314766 nova@sh-teruiop.com China 467 58

View Lastest Price from Proparacaine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Proparacaine Hydrochloride pictures 2024-11-18 Proparacaine Hydrochloride
5875-06-9
US $0.00 / g 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Proparacaine hydrochloride pictures 2024-10-25 Proparacaine hydrochloride
5875-06-9
US $0.00-0.00 / kg 1kg 99% 500 Wuhan Haorong Biotechnology Co.,Ltd
Proparacaine hydrochloride pictures 2024-10-24 Proparacaine hydrochloride
5875-06-9
US $60.00-20.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD

Proparacaine hydrochloride Spectrum

2-[(3-amino-4-propoxyphenyl)-oxomethoxy]ethyl-diethylammonium chloride PROPARACAINE HCL PROPARACAINE HYDROCHLORIDE 3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride alcaine benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,monohydrochlorid beta-(diethylamino)ethyl3-amino-4-n-propoxybenzoatehydrochloride chibro-heracaine keracaine ophthain ophthainehydrochloride ophthetic Proparacaine hydrochloride, >=99% 2-diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride ProxymetacaineHCL2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE PROXYMETACAINE(2-DIETHYLAMINOETHYL-3-AMINO-4-PROPOXYBENZOATE HYDROCHLORIDE) PROXYMETACAINEHYDROCHLORIDE/PROPARACAINE Proparacaine Hydrochloride (200 mg) 3-amino-4-propoxy-benzoic acid-2-(diethylamino)ethyl ester, hydrochloride (1:1) Proparacaine hydrochloride 2-Diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride 2-(3-amino-4-propoxy-benzoyl)oxyethyl-diethyl-ammonium chloride 2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium chloride 2-(3-amino-4-propoxy-phenyl)carbonyloxyethyl-diethyl-azanium chloride 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride IN STOCK PROPARACAINE HYDROCHLORIDE CAS 5875-06-9 ProparacaineHydrochloride> Proparacaine HydrochL Proparacaine hydrochloride USP/EP/BP Proparacaine hydrochloride Reference Substance 5875-06-9 Proparacaine hydrochloride Proparacaine Hydrochloride (1571001) Proparacaine HCI Proparacaine Hydrochloride, ≥ 98.0% Proparacaine HCl|||Proxymetacaine Hydrochloride 5875-06-9 5875-6-9 C16H26N2O3HCl Topical ophthalmic anesthetic Analytical Standards Analytical Chromatography Product Catalog PON - PT Alphabetic