Cycloastragenol
- CAS No.
- 78574-94-4
- Chemical Name:
- Cycloastragenol
- Synonyms
- Cyclosieversigenin;Cyclogalegenol;purity;cycloastragenol;Astramembrangenin;CYCLOASTRAGENOL(SH);Astragalus Root Extract Cycloastragenol;Cycloastragenol, 98%, from Astragalus membranaceus Bunge;Cycloastragenol(Cyclosiversigenin,Astramembrangenin,Cyclosieversigenin);9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,20R,24S)-
- CBNumber:
- CB22457569
- Molecular Formula:
- C30H50O5
- Molecular Weight:
- 490.72
- MDL Number:
- MFCD24849201
- MOL File:
- 78574-94-4.mol
- MSDS File:
- SDS
Melting point | 241.0 to 245.0 °C |
---|---|
Boiling point | 617.2±55.0 °C(Predicted) |
Density | 1.20±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method.Solubility in DMSO is 98 mg/mL (199.7 mM) |
form | powder to crystal |
pka | 14.57±0.29(Predicted) |
color | White to Almost white |
InChIKey | WENNXORDXYGDTP-XWIGRFCYNA-N |
FDA UNII | X37D9F2L0V |
Cycloastragenol price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHL82509 | Cycloastragenol phyproof?ReferenceSubstance | 78574-94-4 | 10mg | $480 | 2024-03-01 | Buy |
TCI Chemical | C3469 | Cycloastragenol | 78574-94-4 | 25mg | $34 | 2024-03-01 | Buy |
TCI Chemical | C3469 | Cycloastragenol | 78574-94-4 | 100mg | $89 | 2024-03-01 | Buy |
TRC | C987618 | Cycloastragenol | 78574-94-4 | 100mg | $125 | 2021-12-16 | Buy |
Chem-Impex | 36989 | Cycloastragenol,≥99%(HPLC) ≥99%(HPLC) | 78574-94-4 | 5G | $946.4 | 2021-12-16 | Buy |
Cycloastragenol Chemical Properties,Uses,Production
Description
Cycloastragenol is the genuine sapogenin of astragaloside IV, a major bioactive constituent of the Chineseherbal medicine Astragali Radix (Huang-Qi). Astragaloside IV exhibits various pharmacological properties, suchas anti-viral, anti-inflammatory, anti-aging,and antioxidant activities.Cycloastragenol is a telomerase activator,which delays the onset of cellularaging. Thus, cycloastragenol is considered as a newgeneration of anti-aging agent.
Uses
Cycloastragenol, a saponin and aglycone found in Astragalus, is a natural triterpenoid. It has anti-aging properties and can also act as an adjuvant therapy for cancer by enhancing the effectiveness of anti-cancer drugs, reducing their toxicity, and preventing/treating leukopenia caused by these treatments.
Definition
ChEBI: Cycloastragenol is a sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus. It has a role as a metabolite. It is a sapogenin, a pentacyclic triterpenoid, a tetrol and a member of oxolanes. It derives from a hydride of a 5alpha-gonane.
Preparation
The cycloastragenol was prepared by acid hydrolysis, and the oxidation reaction was carried out before the hydrolysis. The technological process is: oxidation-reduction-hydrolysis-extraction.
benefits
Cycloastragenol has a steroidal skeleton of tetracyclic triterpene and possess diverse pharmacological activities such as anti-aging, anti-inflammatory, anti-fibrosis, pro-wound healing, liver protection and endothelial protection.
A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications
Biological Activity
Cycloastragenol(78574-94-4), a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].
Biochem/physiol Actions
Cycloastragenol is used as a nutraceutical (e.g. TAT2) and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. Cycloastragenol possesses antiviral, antimicrobial, anti-inflammatory, anti-hepatotoxic, anti-leukemia, antitumor and antinociceptive activity. It also acts as an immunomodulator.
Side effects
Cycloastragenol is a telomerase activator. Fortunately, the experimental results did not show an increased risk of cancer and other adverse effects.
Source
Cycloastragenol is isolated from Astragalus species.
Dosage
As a dietary supplement, take one 100mg capsule of Cycloastragenol daily.
References
[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and PharmacokineticsVolume 25, Issue 5, 2010, Pages 477-486
[2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04
[3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.
Cycloastragenol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Mingrunda New Materials Technology Co., Ltd | +86 13482725029 13482725029 | sales@mrdchem.com | China | 1012 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3003 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 326 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1142 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9340 | 55 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
View Lastest Price from Cycloastragenol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-04 | Cycloastragenol
78574-94-4
|
US $70.00-20.00 / G | 100G | 98% up, High Density | 20 tons | Sinoway Industrial co., ltd. | ||
2024-06-03 | Cycloastragenol
78574-94-4
|
US $0.00-0.00 / g | 1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-05-30 | Cycloastragenol
78574-94-4
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 3.5%-98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
- Cycloastragenol
78574-94-4
- US $70.00-20.00 / G
- 98% up, High Density
- Sinoway Industrial co., ltd.
- Cycloastragenol
78574-94-4
- US $0.00-0.00 / g
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
- Cycloastragenol
78574-94-4
- US $0.00-0.00 / kg
- 3.5%-98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.