Cycloastragenol
- CAS No.
- 78574-94-4
- Chemical Name:
- Cycloastragenol
- Synonyms
- Cyclosieversigenin;Cyclogalegenol;purity;cycloastragenol;Astramembrangenin;CYCLOASTRAGENOL(SH);Cycloastragenol Powder;Cycloastragenol, 10 mM in DMSO;Astragalus Root Extract Cycloastragenol;Cycloastragenol, 98%, from Astragalus membranaceus Bunge
- CBNumber:
- CB22457569
- Molecular Formula:
- C30H50O5
- Molecular Weight:
- 490.72
- MDL Number:
- MFCD24849201
- MOL File:
- 78574-94-4.mol
- MSDS File:
- SDS
| Melting point | 241.0 to 245.0 °C |
|---|---|
| Boiling point | 617.2±55.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method.Solubility in DMSO is 98 mg/mL (199.7 mM) |
| pka | 14.57±0.29(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| optical activity | [α]/D +45 to +60°, c =1 in methanol |
| InChIKey | WENNXORDXYGDTP-XWIGRFCYNA-N |
| FDA UNII | X37D9F2L0V |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
Cycloastragenol price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82509 | Cycloastragenol phyproof?ReferenceSubstance | 78574-94-4 | 10mg | $480 | 2024-03-01 | Buy |
| TCI Chemical | C3469 | Cycloastragenol | 78574-94-4 | 25mg | $34 | 2024-03-01 | Buy |
| TCI Chemical | C3469 | Cycloastragenol | 78574-94-4 | 100mg | $89 | 2024-03-01 | Buy |
| TRC | C987618 | Cycloastragenol | 78574-94-4 | 100mg | $125 | 2021-12-16 | Buy |
| Chem-Impex | 36989 | Cycloastragenol,≥99%(HPLC) ≥99%(HPLC) | 78574-94-4 | 5G | $946.4 | 2021-12-16 | Buy |
Cycloastragenol Chemical Properties,Uses,Production
Description
Cycloastragenol is the genuine sapogenin of astragaloside IV, a major bioactive constituent of the Chineseherbal medicine Astragali Radix (Huang-Qi). Astragaloside IV exhibits various pharmacological properties, suchas anti-viral, anti-inflammatory, anti-aging,and antioxidant activities.Cycloastragenol is a telomerase activator,which delays the onset of cellularaging. Thus, cycloastragenol is considered as a newgeneration of anti-aging agent.
Uses
Cycloastragenol, a saponin and aglycone found in Astragalus, is a natural triterpenoid. It has anti-aging properties and can also act as an adjuvant therapy for cancer by enhancing the effectiveness of anti-cancer drugs, reducing their toxicity, and preventing/treating leukopenia caused by these treatments.
Definition
ChEBI: Cycloastragenol is a sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus. It has a role as a metabolite. It is a sapogenin, a pentacyclic triterpenoid, a tetrol and a member of oxolanes. It derives from a hydride of a 5alpha-gonane.
Preparation
The cycloastragenol was prepared by acid hydrolysis, and the oxidation reaction was carried out before the hydrolysis. The technological process is: oxidation-reduction-hydrolysis-extraction.
benefits
Cycloastragenol has a steroidal skeleton of tetracyclic triterpene and possess diverse pharmacological activities such as anti-aging, anti-inflammatory, anti-fibrosis, pro-wound healing, liver protection and endothelial protection.
A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications
Biological Activity
Cycloastragenol(78574-94-4), a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].
Biochem/physiol Actions
Cycloastragenol is used as a nutraceutical (e.g. TAT2) and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. Cycloastragenol possesses antiviral, antimicrobial, anti-inflammatory, anti-hepatotoxic, anti-leukemia, antitumor and antinociceptive activity. It also acts as an immunomodulator.
Side effects
Cycloastragenol is a telomerase activator. Fortunately, the experimental results did not show an increased risk of cancer and other adverse effects.
Source
Cycloastragenol is isolated from Astragalus species.
Dosage
As a dietary supplement, take one 100mg capsule of Cycloastragenol daily.
References
[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and PharmacokineticsVolume 25, Issue 5, 2010, Pages 477-486
[2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04
[3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.
Cycloastragenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu King-tiger Pharm-chem. Tech. Co., Ltd. | +86-28-85317716 +86-18202897410 | sales@king-tiger.com | China | 6 | 58 |
| Hubei Danding Pharmaceutical Technology Co., Ltd | +86-18917019315 +86-13173601896 | 3582572959@qq.com | China | 496 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3007 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3712 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | FandaChem@Gmail.com | China | 8241 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29871 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Cycloastragenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-18 | Cycloastragenol Powder
78574-94-4
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-02-18 | Cycloastragenol
78574-94-4
|
US $0.00-0.00 / g | 1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2025-02-18 | Cycloastragenol
78574-94-4
|
US $0.00-0.00 / G | 100G | 98% up, High Density | 20 tons | Sinoway Industrial co., ltd. |
-
- Cycloastragenol Powder
78574-94-4
- US $150.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Cycloastragenol
78574-94-4
- US $0.00-0.00 / g
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Cycloastragenol
78574-94-4
- US $0.00-0.00 / G
- 98% up, High Density
- Sinoway Industrial co., ltd.