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LY411575

CAS No.
209984-57-6
Chemical Name:
LY411575
Synonyms
CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor;(S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib
CBNumber:
CB22464309
Molecular Formula:
C26H23F2N3O4
Molecular Weight:
479.48
MDL Number:
MFCD09832551
MOL File:
209984-57-6.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

LY411575 Properties

Boiling point 836.0±65.0 °C(Predicted)
Density 1.40
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear
form powder
pka 11.79±0.20(Predicted)
color white to beige
InChIKey ULSSJYNJIZWPSB-CVRXJBIPSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  24/25
WGK Germany  3
HS Code  29337900

LY411575 price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0506 LY-411575 ≥97% (HPLC) 209984-57-6 5mg $128 2024-03-01 Buy
Sigma-Aldrich SML0506 LY-411575 ≥97% (HPLC) 209984-57-6 25mg $514 2024-03-01 Buy
Cayman Chemical 16162 LY411575 ≥98% 209984-57-6 1mg $37 2024-03-01 Buy
Cayman Chemical 16162 LY411575 ≥98% 209984-57-6 5mg $116 2024-03-01 Buy
Cayman Chemical 16162 LY411575 ≥98% 209984-57-6 10mg $213 2024-03-01 Buy
Product number Packaging Price Buy
SML0506 5mg $128 Buy
SML0506 25mg $514 Buy
16162 1mg $37 Buy
16162 5mg $116 Buy
16162 10mg $213 Buy

LY411575 Chemical Properties,Uses,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Uses

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Definition

ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

target

γ-secretase

LY411575 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 127)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32956 60
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 11840 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58

View Lastest Price from LY411575 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LY-411575 pictures 2024-11-19 LY-411575
209984-57-6
US $38.00-107.00 / mg 99.38% 10g TargetMol Chemicals Inc.
LY411575 pictures 2020-01-08 LY411575
209984-57-6
US $0.01 / KG 1KG 98%; 99% 1kg; 10kg; 25kg Career Henan Chemical Co
  • LY-411575 pictures
  • LY-411575
    209984-57-6
  • US $38.00-107.00 / mg
  • 99.38%
  • TargetMol Chemicals Inc.
  • LY411575 pictures
  • LY411575
    209984-57-6
  • US $0.01 / KG
  • 98%; 99%
  • Career Henan Chemical Co

LY411575 Spectrum

LY411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide (S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)- (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575 LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LSN-411575 N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide LY411575, >=98% LY-411575;LY411575; LY 411575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib LY411575, 98%, a γ-secretase inhibitor CS-509 LY411575;LY 411575 LY-411575 >=97% (HPLC) LY4114575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide 209984-57-6 C26H23F2N3O4 Inhibitor Inhibitors