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OSU-03012

OSU-03012 structure

CAS No.: 742112-33-0

Chemical Name:: OSU-03012

Synonyms: AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;N/AAR-12; OSU03012; OSU 03012;Osu-03012|||Osu 03012|||AR-12

CBNumber:: CB22501006

Molecular Formula:: C26H19F3N4O

Molecular Weight:: 460.45

MDL Number:: MFCD12912272

MOL File:: 742112-33-0.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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OSU-03012 Properties

storage temp.	Store at -20°C
solubility	≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
color	White to off-white
CAS DataBase Reference	742112-33-0
FDA UNII	EX3O2Q61UV

OSU-03012 price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10008005	OSU03012	742112-33-0	10mg	$116	2024-03-01	Buy
Cayman Chemical	10008005	OSU03012	742112-33-0	100mg	$789	2024-03-01	Buy
Cayman Chemical	10008005	OSU03012	742112-33-0	5mg	$73	2024-03-01	Buy
Cayman Chemical	10008005	OSU03012	742112-33-0	50mg	$502	2024-03-01	Buy
Tocris	5682	OSU03012 ≥98%(HPLC)	742112-33-0	50	$648	2021-12-16	Buy

Product number	Packaging	Price	Buy
10008005	10mg	$116	Buy
10008005	100mg	$789	Buy
10008005	5mg	$73	Buy
10008005	50mg	$502	Buy
5682	50	$648	Buy

OSU-03012 Chemical Properties,Uses,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC₅₀ value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

OSU-03012 Suppliers

Global( 129)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22783	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from OSU-03012 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Osu03012 742112-33-0	US $31.00-79.00 / mg		99.22%	10g	TargetMol Chemicals Inc.
	2019-07-06	OSU-03012 742112-33-0	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

Osu03012
742112-33-0
US $31.00-79.00 / mg
99.22%
TargetMol Chemicals Inc.

OSU-03012
742112-33-0
US $2.00 / kg
99%
Career Henan Chemical Co

OSU-03012 Spectrum

OSU-03012(742112-33-0)¹HNMR

742112-33-0(OSU-03012)Related Search:

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1of3

OSU-03012, >=98% OSU-03012 (AR-12) 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 N/AAR-12 OSU-03012 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012 CS-1848 N/AAR-12; OSU03012; OSU 03012 Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- OSU-03012 USP/EP/BP AR-12 Osu-03012|||Osu 03012|||AR-12 PDK1 inhibitor AR-12 742112-33-0 C26H19F3N4O Inhibitors Inhibitor of phosphoinositide-dependent kinase-1. Akt mTOR PI3K