ChemicalBook >> CAS DataBase List >>Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
- CAS No.
- 323176-93-8
- Chemical Name:
- Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
- Synonyms
- Venlafaxine IMpurity B;Venlafaxine EP IMpurity B;Venlafaxine EP Impurity B HCl;Ethyl (2RS)-3-(Dimethylamino)-2-(4-;ethyl 3-(dimethylamino)-2-(4-methoxyphenyl);ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Ethyl 3-Dimethylamino-2-(4-methoxy-phenyl)-propionate;Venlafaxine EP Impurity B (Venlafaxine Ester Impurity)
- CBNumber:
- CB22508656
- Molecular Formula:
- C14H21NO3
- Molecular Weight:
- 251.32
- MDL Number:
- MFCD16293840
- MOL File:
- 323176-93-8.mol
- MSDS File:
- SDS
Last updated:2023-04-23 13:52:06
| Boiling point | 337.9±42.0 °C(Predicted) |
|---|---|
| Density | 1.045±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 8.61±0.28(Predicted) |
| color | Pale Brown to Light Brown |
| FDA UNII | 20A3002JTT |
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E925055 | Ethylα-(p-Methoxyphenyl)-β-(dimethylamino)propionate | 323176-93-8 | 50mg | $185 | 2021-12-16 | Buy |
| AK Scientific | 7161CS | Ethylalpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate | 323176-93-8 | 250mg | $399 | 2021-12-16 | Buy |
| AK Scientific | 7161CS | Ethylalpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate | 323176-93-8 | 500mg | $671 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0293941 | ALPHA-[(DIMETHYLAMINO)METHYL]-4-METHOXYBENZENEACETIC ACID ETHYL ESTER 95.00% | 323176-93-8 | 100MG | $704.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0293941 | ALPHA-[(DIMETHYLAMINO)METHYL]-4-METHOXYBENZENEACETIC ACID ETHYL ESTER 95.00% | 323176-93-8 | 1G | $1593.9 | 2021-12-16 | Buy |
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Chemical Properties,Uses,Production
Synthesis
A mixture of ethyl p-methoxyphenylacetate (4 g, 20.62 mmol), paraformaldehyde (1.05 g, 35.0 mmol) and TBAI (0.381 g, 1.03 mmol) was heated in PhMe (16 ml) at 80-85 ºC for 3.5 hours. The reaction mixture was allowed to cool. Then, a solution of Me2NH in THF was added to the reaction mixture at 0 ºC in the presence of catalytic FeCl3 (0.160 g, 0.001 mol) and stirred for 45 minutes. After completion of the reaction, 100 ml water was added to the reaction mixture and aqueous layer was acidified with conc. HCl (pH = 2). Aqueous layer was washed with DCM (3x 50 ml) and made alkaline (pH = 8) using 5% NaOH solution, extracted with DCM (3x 50 ml), washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Column chromatographic purification over silca gel (0.5% MeOH in CHCl3) furnished aminoester 65 as a thick colourless oil (3.08 g). When the reaction was carried out without catalyst, it took 48 hours for completetion.
Uses
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate (Venlafaxine EP Impurity B) is an impurity of Venlafaxine (impurity B).
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 62)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30241 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | chenyj@titansci.com | China | 14103 | 59 |
323176-93-8(Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate)Related Search:
O-Desmethylvenlafaxine
1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride
(5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride
Venlafaxine Related Compound A (10 mg) (1-(1-(4-Methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol hydrochloride)
D,L-N,N-Didesmethyl-N-(4-methoxyphenethyl) Venlafaxine
Desvenlafaxine (O-DesMethyl Venlafaxine) FuMarate
(2RS)-2-(Cyclohex-1-enyl)-2-(4-Methoxyphenyl)-N,N-diMethylethanaMine Hydrochloride
DESVENLAFAXINE SUCCINATE
Venlafaxine N-Dimer
Venlafaxine Impurity1
1of4
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
Ethyl (2RS)-3-(DiMethylaMino)-2-(4-Methoxyphenyl)propanoate Hydrochloride
Venlafaxine EP Impurity B HCl
ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate
α-[(DiMethylaMino)Methyl]-4-Methoxybenzeneacetic Acid Ethyl Ester
Venlafaxine EP IMpurity B
Venlafaxine IMpurity B
D,L N,O-Didesmethylvenlafaxine (Venlafaxine Impurity B)
ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)
Venlafaxine impurity 2/Venlafaxine EP Impurity B HCl/Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate hydrochloride
Ethyl (2RS)-3-(Dimethylamino)-2-(4-
Benzeneacetic acid, α-[(dimethylamino)methyl]-4-methoxy-, ethyl ester
Venlafaxine EP Impurity B (Venlafaxine Ester Impurity)
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate (Venlafaxine Impurity)
Ethyl 3-Dimethylamino-2-(4-methoxy-phenyl)-propionate
323176-93-8
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