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AM-1220

AM-1220 Structure
AM-1220 structure
CAS No.
137642-54-7
Chemical Name:
AM-1220
Synonyms
AM-1220;[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]-naphthalen-1-ylmethanone;[1-[(1-Methyl-2-piperidinyl)Methyl]-1H-indol-3-yl]-1-naphthalenylMethanone;(1-((1-Methylpiperidin-2-yl)Methyl)-1H-indol-3-yl)(naphthalen-1-yl)Methanone;Methanone, [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-1-naphthalenyl-
CBNumber:
CB22534516
Molecular Formula:
C26H26N2O
Molecular Weight:
382.5
MDL Number:
MFCD00947094
MOL File:
137642-54-7.mol
Last updated:2023-06-08 09:03:09

AM-1220 Properties

Boiling point 575.6±20.0 °C(Predicted)
Density 1.17
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 0.15 mg/ml; Methanol: 1 mg/ml
form A crystalline solid
pka 9.75±0.10(Predicted)
FDA UNII 05850M72P2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H361-H373
Precautionary statements  P201-P202-P260-P280-P308+P313-P314-P405-P501

AM-1220 Chemical Properties,Uses,Production

Description

AM1220 is a potent synthetic cannabinoid (CB) with preference for the central CB1 receptor (Ki = 3.88 nM) over the CB2 receptor (Ki = 73.4 nM). The physiological actions and metabolism of AM1220 have not been characterized.

Uses

AM-1220 is a synthetic cannabimimetic indole derivative. AM-1220 acts as a potent and moderately selective agonist for the cannabinoid receptor CB1 with around 19 times the selectivity for CB1 over CB2 receptor.

AM-1220 Preparation Products And Raw materials

Raw materials

Preparation Products

AM-1220 Methanone, [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-1-naphthalenyl- (1-((1-Methylpiperidin-2-yl)Methyl)-1H-indol-3-yl)(naphthalen-1-yl)Methanone [1-[(1-Methyl-2-piperidinyl)Methyl]-1H-indol-3-yl]-1-naphthalenylMethanone [1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]-naphthalen-1-ylmethanone 137642-54-7 Amines Heterocycles Indole Derivatives Intermediates & Fine Chemicals Pharmaceuticals Research Chemical Chemical for Research