ChemicalBook >> CAS DataBase List >>2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin structure

CAS No.: 599150-20-6

Chemical Name:: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

Synonyms: HPI 1;GLI antagonist-1;Hedgehog Pathway Inhibitor 1;Hh Signaling Antagonist XII, HPI-1;Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin;4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one;2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

CBNumber:: CB22557144

Molecular Formula:: C27H29NO6

Molecular Weight:: 463.52

MDL Number:: MFCD03312466

MOL File:: 599150-20-6.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:03

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2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Properties

Boiling point	638.2±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO
pka	9.67±0.10(Predicted)
form	Pale yellow solid
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H400
Precautionary statements	P273
Hazard Codes	Xn,N
Risk Statements	22-50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
HazardClass	IRRITANT

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H1542	HPI-1 hydrate	599150-20-6	5mg	$134	2024-03-01	Buy
Sigma-Aldrich	373275	Hh Signaling Antagonist XII, HPI-1	599150-20-6	10mg	$280	2023-01-07	Buy
Cayman Chemical	15221	HPI-1 ≥95%	599150-20-6	10mg	$142	2021-12-16	Buy
Cayman Chemical	15221	HPI-1 ≥95%	599150-20-6	5mg	$79	2021-12-16	Buy
Sigma-Aldrich	H1542	HPI-1 hydrate	599150-20-6	25mg	$530	2024-03-01	Buy

Product number	Packaging	Price	Buy
H1542	5mg	$134	Buy
373275	10mg	$280	Buy
15221	10mg	$142	Buy
15221	5mg	$79	Buy
H1542	25mg	$530	Buy

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Chemical Properties,Uses,Production

Uses

HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.

General Description

A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu^+/+ NIH 3T3 (shh-LIGHT2) and Sufu^-/- fibroblast cultures (IC₅₀ = 1.5 & 3 μM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 μM), remains effective against Sufu^-/- fibroblasts overexpressing Gli1 or Gli2 (IC₅₀ = 6 & 4 μM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.

Biological Activity

hedgehog (hh) signaling inhibitor. inhibits sonic hedgehog (shh)-, sag- and gli-induced hh pathway activation in shh-light2 cells (ic50 values are 1.5, 1.5, 4 and 6 μm for shh-, sag-, gli2- and gli1-induced activation). also inhibits hh pathway activation

storage

Store at -20°C

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Suppliers

Global( 56)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Jiangsu aikang biomedical research and development co., LTD	025-66110311 13155353615	qzhang@aikonchem.com	China	15527	58
BOC Sciences	--	info@bocsci.com	USA	0	65
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
EMMX Biotechnology LLC	60
Jiangsu aikang biomedical research and development co., LTD	58
BOC Sciences	65
DC Chemicals	58
MedBioPharmaceutical Technology Inc	58
Energy Chemical	58
TargetMol Chemicals Inc.	58

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Spectrum

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin(599150-20-6)¹HNMR

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate Hedgehog Pathway Inhibitor 1 HPI 1 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui Hh Signaling Antagonist XII, HPI-1 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester 4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one SUM149,anti-proliferative,inhibit,colony formation,Gli,HPI 1,GLI1 mRNA,SUM159 cells,GLI antagonist1,GLI antagonist-1,Inhibitor,GLI antagonist 1 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-, 2-methoxyethyl ester GLI antagonist-1 599150-20-6