HZ-52
- CAS No.
- 1077626-51-7
- Chemical Name:
- HZ-52
- Synonyms
- HZ-52;MLNIGXYHGQLWLD-UHFFFAOYSA-N;2-[[4-([1,1'-biphenyl]-4-ylaMino)-6-chloro-2-pyriMidinyl]thio]octanoic Acid;Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-
- CBNumber:
- CB22558358
- Molecular Formula:
- C24H26ClN3O2S
- Molecular Weight:
- 456
- MDL Number:
- MFCD28138598
- MOL File:
- 1077626-51-7.mol
HZ-52 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10888 | HZ52 ≥98% | 1077626-51-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10888 | HZ52 ≥98% | 1077626-51-7 | 5mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 10888 | HZ52 ≥98% | 1077626-51-7 | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 10888 | HZ52 ≥98% | 1077626-51-7 | 25mg | $442 | 2024-03-01 | Buy |
| Usbiological | 014693 | HZ-52 | 1077626-51-7 | 10mg | $460 | 2021-12-16 | Buy |
HZ-52 Chemical Properties,Uses,Production
Uses
A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
Definition
ChEBI: HZ52 is a member of biphenyls.
Biological Activity
2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2- ylthio)octanoic acid (hz52) is an inhibitor for 5-lipoxygenase (5-lo) [1]. 5-lipoxygenase (5-lo), the key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes (lts), is a potential target for pharmacological intervention with inflammation and allergic disorders [1].
in vitro
in cell-free assays using partially purified recombinant 5-lo enzyme, hz52 inhibited 5-lo with an ic50 of 1.5 μm. in pmnl homogenates, hz52 inhibited 5-lo with an ic50 of 9 μm [1]. hz52 (10 or 30 μm) promoted 5-lo translocation to the nuclear membrane in pmnl [1]. the cell-based and cell-free assays revealed that inhibition of 5-lo by hz52 did not depend on radical scavenging properties and was reversible [1].
in vivo
in rats with carrageenan-induced pleurisy and in mice bearing platelet-activating factor (paf)-induced lethal shock, hz52 (1.5 mg/kg, i.p) prevented carrageenan-induced pleurisy accompanied by reducing ltb4 levels. hz52 protected mice (10 mg/kg, i.p) against paf-induced shock. [1].
References
[1] greiner c, hrnig c, rossi a, et al. 2‐(4‐(biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio) octanoic acid (hz52)–a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo[j]. british journal of pharmacology, 2011, 164(2b): 781-793.
HZ-52 Preparation Products And Raw materials
Raw materials
Preparation Products
HZ-52 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |