L-765,314
- CAS No.
- 189349-50-6
- Chemical Name:
- L-765,314
- Synonyms
- Adrenergic Receptor,L-765314,Inhibitor,Beta Receptor,L765314,inhibit,L 765314;Benzyl (S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-, phenylmethyl ester, (S)-;1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-, phenylmethyl ester, (2S)-
- CBNumber:
- CB22642473
- Molecular Formula:
- C27H34N6O5
- Molecular Weight:
- 522.6
- MDL Number:
- MFCD05664727
- MOL File:
- 189349-50-6.mol
- MSDS File:
- SDS
Density | 1.269±0.06 g/cm3(Predicted) |
---|---|
storage temp. | 2-8°C(protect from light) |
solubility |
DMSO:75.0(Max Conc. mg/mL);143.51(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);191.35(Max Conc. mM) |
pka | 14.99±0.20(Predicted) |
form | Solid |
color | White to off-white |
FDA UNII | CR7JLF2GBM |
L-765,314 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0021271 | L-765314 99.77% | 189349-50-6 | 5mg | $110 | 2021-12-16 | Buy |
ChemScene | CS-0021271 | L-765314 99.77% | 189349-50-6 | 10mg | $180 | 2021-12-16 | Buy |
ChemScene | CS-0021271 | L-765314 99.77% | 189349-50-6 | 25mg | $350 | 2021-12-16 | Buy |
ChemScene | CS-0021271 | L-765314 99.77% | 189349-50-6 | 50mg | $550 | 2021-12-16 | Buy |
ChemScene | CS-0021271 | L-765314 99.77% | 189349-50-6 | 100mg | $950 | 2021-12-16 | Buy |
L-765,314 Chemical Properties,Uses,Production
Biological Activity
L-765314 is a potent and selective antagonist of the α1b adrenergic receptor with Ki values of 5.4 nM and 2.0 nM in rat and human, respectively.
in vitro
L-765314 exhibits two displacement sites. The high-affinity site accounts for approximately 25% of binding (IC 50 ) 1.90 nM and represents binding to the R1b sites. The low- affinity site accounts for the residual 75% of binding (IC 50 ) 790 nM and represents binding to the R1a sites.
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in vivo
The results of plasma assayed by liquid chromatograph/mass spectrometer (LCMS) show that the mean C max of L-765314 (A322312) is 1.05 μM and the t 1 /2 is 0.5 h. It shows weak potency for inhibiting the pressor response to either phenylephrine or A-61603 (AD 25 >3 mg/kg for each). On the basis of the inhibition of pressor responses to the R1a subtype selective agonist A-61603, it appears to be selective versus the R1a receptor up to a dose of 0.3 mg/kg. The results of hypotensive potency in rats show that both L- 765314 and terazosin tend to decrease heart rate (about 25 bpm at 1 mg/kg iv).
target
Ki: 5.4±0.6 nM (rat α1b receptor ), 2.0±0.66 nM (human α1b receptor), 50±8 nM (rat α1d receptor), 34±6 nM (human α1d receptor), 500± 20 nM (rat α1b receptor ), 420±62 nM (human α1b receptor).
L-765,314 Preparation Products And Raw materials
Raw materials
Preparation Products
L-765,314 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 8047 | 58 |
Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5010 | 55 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2988 | 58 |
Shanghai Chaolan Chemical Technology Center | 021-QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 7296 | 58 |