ChemicalBook >> CAS DataBase List >>CID-2858522
CID-2858522
- CAS No.
- 758679-97-9
- Chemical Name:
- CID-2858522
- Synonyms
- 100844;CID-2858522;CID 2858522;CID2858522;1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imid;CID 2858522,Nuclear factor-kappaB,CID-2858522,NF-κB,Nuclear factor-κB,inhibit,CID2858522,Inhibitor;1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylaMino)-5,6-diMethyl-1H-benzo[d]iMidazol-1-yl)ethanone;1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone;Ethanone, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-
- CBNumber:
- CB22642741
- Molecular Formula:
- C28H39N3O3
- Molecular Weight:
- 465.63
- MDL Number:
- MFCD20755108
- MOL File:
- 758679-97-9.mol
Last updated:2023-09-04 15:51:00
| Boiling point | 618.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| pka | 8.46±0.40(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | Z744D8S6JG |
CID-2858522 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0634 | CID2858522 ≥98% (HPLC) | 758679-97-9 | 25mg | $425 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0634 | CID2858522 ≥98% (HPLC) | 758679-97-9 | 5mg | $95.7 | 2022-05-15 | Buy |
| Cayman Chemical | 14122 | CID-2858522 ≥98% | 758679-97-9 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 14122 | CID-2858522 ≥98% | 758679-97-9 | 5mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 14122 | CID-2858522 ≥98% | 758679-97-9 | 10mg | $127 | 2024-03-01 | Buy |
CID-2858522 Chemical Properties,Uses,Production
Uses
1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone is a selective benzimidazole inhibitor of the antigen receptor-mediated NF-κB activation pathway.
Definition
ChEBI: 1-(3,5-ditert-butyl-4-hydroxyphenyl)-2-[2-(3-hydroxypropylamino)-5,6-dimethyl-1-benzimidazolyl]ethanone is an aromatic ketone.
Biochem/physiol Actions
CID2858522 specifically inhibits NF-kB activation downstream of protein kinsase C (PKC). CID2858522 dose dependently inhibits NF-kB reporter activity in PMA-ionomycin stimulated HEK293 cells, but does not affect NF-kB activity in cells challenged with TNFa, retinoic acid, or stimulation of the toll-like receptor signaling pathway.
CID-2858522 Preparation Products And Raw materials
Raw materials
Preparation Products
CID-2858522 Suppliers
Global( 72)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemShuttle, Inc. | 0510-83588313-802 18800520310; | sales@chemshuttle.com | China | 2993 | 62 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1785 | 58 | |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9798 | 50 |
CID-2858522
1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylaMino)-5,6-diMethyl-1H-benzo[d]iMidazol-1-yl)ethanone
1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone
1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imid
CID 2858522;CID2858522
100844
Ethanone, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-
CID 2858522,Nuclear factor-kappaB,CID-2858522,NF-κB,Nuclear factor-κB,inhibit,CID2858522,Inhibitor
758679-97-9
NF-kB