ChemicalBook >> CAS DataBase List >>(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
- CAS No.
- 85416-75-7
- Chemical Name:
- (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
- Synonyms
- CS-1181;(?)-Rolipram;(-)-Rolipram;(R)-(-)-ROLIPRAM;(S)-(+)-ROLIPRAM;Rolipram (R)-(-)-;(R)-(-)-Rolipram;(R)-ROLIPRAM;(-)-ROLIPRAM;4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone;(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
- CBNumber:
- CB2264846
- Molecular Formula:
- C16H21NO3
- Molecular Weight:
- 275.34
- MDL Number:
- MFCD03093860
- MOL File:
- 85416-75-7.mol
Last updated:2023-06-30 15:45:59
Melting point | 132.0 to 136.0 °C |
---|---|
Boiling point | 472.7±45.0 °C(Predicted) |
Density | 1.155±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 16.02±0.40(Predicted) |
form | White to off-white solid. |
color | Off-White |
FDA UNII | DPX51KUP08 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H332-H335 |
Precautionary statements | P261-P280-P305+P351+P338 |
HS Code | 2933.79.8500 |
HazardClass | IRRITANT |
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | R0182 | (R)-(-)-Rolipram >98.0%(HPLC) | 85416-75-7 | 10mg | $158 | 2024-03-01 | Buy |
TCI Chemical | R0182 | (R)-(-)-Rolipram >98.0%(HPLC) | 85416-75-7 | 50mg | $549 | 2024-03-01 | Buy |
Tocris | 1349 | (R)-(-)-Rolipram ≥98%(HPLC) | 85416-75-7 | 50 | $876 | 2021-12-16 | Buy |
Tocris | 1349 | (R)-(-)-Rolipram ≥98%(HPLC) | 85416-75-7 | 10 | $212 | 2021-12-16 | Buy |
TRC | R640043 | R-(-)-Rolipram | 85416-75-7 | 5mg | $140 | 2021-12-16 | Buy |
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties,Uses,Production
Uses
R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.
Definition
ChEBI: (-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.
Biological Activity
More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
storage
Room temperature
![141332-74-3](/CAS/20180702/GIF/141332-74-3.gif)
![108-59-8](/CAS/GIF/108-59-8.gif)
![85416-75-7](/CAS/GIF/85416-75-7.gif)
![85416-73-5](/CAS/GIF/85416-73-5.gif)
Synthesis of (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE from (E)-2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene and Dimethyl malonate
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 91)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11506 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7431 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
View Lastest Price from (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
|
2021-01-06 | (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
85416-75-7
|
US $1.00 / g | 1g | 85.0-99.8% | 20ton | Career Henan Chemica Co |
-
- (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
85416-75-7
- US $1.00 / g
- 85.0-99.8%
- Career Henan Chemica Co
85416-75-7((4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE)Related Search:
(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(S)-(+)-ROLIPRAM
(R)-(-)-ROLIPRAM
(4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
Rolipram (R)-(-)-
(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(R)-(-)-Rolipram
4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
(R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
CS-1181
(R)-ROLIPRAM;(-)-ROLIPRAM
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-
(?)-Rolipram
(-)-Rolipram
Inhibitor,inhibit,Phosphodiesterase (PDE),(R)()Rolipram,(R) ( ) Rolipram
85416-75-7
Signalling
Cyclic Nucleotide related