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WEHI-539

WEHI-539 structure

CAS No.: 1431866-33-9

Chemical Name:: WEHI-539

Synonyms: CS-1739;WEHI-539;WEHI539;WEHI 539;WEHI-539 ( CT-WE539);(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr;5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid;5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-;(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid

CBNumber:: CB22655422

Molecular Formula:: C31H29N5O3S2

Molecular Weight:: 583.72

MDL Number:: MFCD25372044

MOL File:: 1431866-33-9.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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WEHI-539 Properties

Boiling point	827.6±75.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
pka	10.24±0.20(Predicted)

WEHI-539 price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21478	WEHI-539 ≥98%	1431866-33-9	1mg	$57	2024-03-01	Buy
Cayman Chemical	21478	WEHI-539 ≥98%	1431866-33-9	5mg	$233	2024-03-01	Buy
Cayman Chemical	21478	WEHI-539 ≥98%	1431866-33-9	10mg	$412	2024-03-01	Buy
TRC	W498725	WEHI539	1431866-33-9	2.5mg	$195	2021-12-16	Buy
ApexBio Technology	A3935	WEHI-539	1431866-33-9	50mg	$955	2021-12-16	Buy

Product number	Packaging	Price	Buy
21478	1mg	$57	Buy
21478	5mg	$233	Buy
21478	10mg	$412	Buy
W498725	2.5mg	$195	Buy
A3935	50mg	$955	Buy

WEHI-539 Chemical Properties,Uses,Production

Uses

WEHI 539 is a selective BCL-XL inhibitor.

Biological Activity

wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1].

target

BCL-XL

References

[1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.

WEHI-539 Preparation Products And Raw materials

Raw materials

Preparation Products

WEHI-539 Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Nanjing Chemlin Chemical Co., Ltd	025-83697070	info@chemlin.com.cn	China	19172	64
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Jinan Mingya Medical Technology Co., Ltd.	0531-85828981	864598798@qq.com	China	588	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58
Nanjing Chemlin Chemical Co., Ltd	64
MedChemexpress LLC	58
Jinan Mingya Medical Technology Co., Ltd.	58

View Lastest Price from WEHI-539 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	WEHI-539 1431866-33-9	US $143.00 / mg			10g	TargetMol Chemicals Inc.

WEHI-539
1431866-33-9
US $143.00 / mg
TargetMol Chemicals Inc.

1431866-33-9(WEHI-539)Related Search:

4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WEHI-345 WEHI-539 HCl WEHI-345 (analog)

WEHI-539 (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid WEHI-539 ( CT-WE539) 5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid (E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr CS-1739 WEHI539;WEHI 539 4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]- 5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid 1431866-33-9 C31H29N5O3S2