ChemicalBook >> CAS DataBase List >>4-Difluoromethoxy-3-hydroxybenzaldehyde
4-Difluoromethoxy-3-hydroxybenzaldehyde
- CAS No.
- 151103-08-1
- Chemical Name:
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
- Synonyms
- 4-DifL;Roflumilast impurity 19;uoromethoxy-3-hydroxybenzaL;3-Hydroxy-4-diflouromethylbenzaldehyde;4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE;3-hydroxy-4-difluoroMethoxy benzaldehyde;4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde;Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-;4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%;4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
- CBNumber:
- CB2266224
- Molecular Formula:
- C8H6F2O3
- Molecular Weight:
- 188.13
- MDL Number:
- MFCD04406687
- MOL File:
- 151103-08-1.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 85-90°C |
|---|---|
| Boiling point | 280.6±35.0 °C(Predicted) |
| Density | 1.395±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.85±0.35(Predicted) |
| color | White |
| InChI | InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H |
| InChIKey | ZLIKNROJGXXNJG-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(OC(F)F)C(O)=C1 |
| CAS DataBase Reference | 151103-08-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H411 | |||||||||
| Precautionary statements | P261-P273-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-51-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
4-Difluoromethoxy-3-hydroxybenzaldehyde price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4505 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 5G | $165 | 2024-03-01 | Buy |
| TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 10g | $130 | 2021-12-16 | Buy |
| TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 1g | $55 | 2021-12-16 | Buy |
| TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 25g | $280 | 2021-12-16 | Buy |
| Apolloscientific | PC8950 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97% | 151103-08-1 | 25g | $350 | 2021-12-16 | Buy |
4-Difluoromethoxy-3-hydroxybenzaldehyde Chemical Properties,Uses,Production
Description
4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude[1].
Chemical Properties
4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder
Uses
4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.
References
[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3.
4-Difluoromethoxy-3-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 312)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 148 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +852-6619 3215 +86-17731935328 | sales03@chemcn.cn | China | 970 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19841 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29857 | 58 |
View Lastest Price from 4-Difluoromethoxy-3-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $0.00 / kg | 1kg | 99% | 200KG | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2025-03-04 | 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $30.00 / kg | 20kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2025-01-03 | 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $0.00-0.00 / g | 10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $0.00-0.00 / g
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
151103-08-1(4-Difluoromethoxy-3-hydroxybenzaldehyde)Related Search:
Benzaldehyde
4-(Trifluoromethyl)benzaldehyde
4-Ethyl-5-fluoro-6-hydroxypyrimidine
Protocatechualdehyde
Veratraldehyde
(Trifluoromethoxy)benzene
p-Anisaldehyde
4-(Trifluoromethoxy)aniline
2,4-Dihydroxybenzaldehyde
2,4-Dimethoxybenzaldehyde
1of4
2-(Difluoromethoxy)-5-formylphenol, alpha,alpha-Difluoro-4-formyl-2-hydroxyanisole
Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-
3-Hydroxy-4-diflouromethylbenzaldehyde
4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%
3-hydroxy-4-difluoroMethoxy benzaldehyde
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE
Roflumilast impurity 19
4-DifL
uoromethoxy-3-hydroxybenzaL
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE 151103-08-1
4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde
4-Difluoromethoxy-3-hydroxybenzaldehyde, 4-DifluoroMethoxy-3-hydroxybenzaldehyde, 3-Hydroxy-4-difluoromethoxybenzaldehyde, 4-(difluoromethoxy)-3-hydroxybenzaldehyde, Roflumilast impurity 19, Roflumilast-IM F, 3-hydroxy-4-difluoroMethoxy benzaldehyde, 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
151103-08-1
Roflumilast interemdiate
Aromatics
Intermediates
Aldehydes
Phenyls & Phenyl-Het
Phenyls & Phenyl-Het
Intermediate