Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>MonoMethyl Dolastatin 10

MonoMethyl Dolastatin 10

MonoMethyl Dolastatin 10 Structure
MonoMethyl Dolastatin 10 structure
CAS No.
203849-91-6
Chemical Name:
MonoMethyl Dolastatin 10
Synonyms
MMAD;CS-1368;EOS-60620;DeMethyldolastatin 10;MonoMethylauristatin D;MonoMethyl Dolastatin 10;Demethyldolastatin (MMAD);MMAD (Demethyldolastatin 10;MMAD MonoMethyl Dolastatin 10;MonoMethyl Dolastatin 10 / MMAD
CBNumber:
CB22666664
Molecular Formula:
C41H66N6O6S
Molecular Weight:
771.06
MDL Number:
MFCD25976743
MOL File:
203849-91-6.mol
Last updated:2024-07-02 08:55:03
Request For Quotation

MonoMethyl Dolastatin 10 Properties

Boiling point 906.1±65.0 °C(Predicted)
Density 1.119±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO
form Powder
pka 13.81±0.46(Predicted)
color White to off-white
FDA UNII W4ZIA40FZ9

MonoMethyl Dolastatin 10 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M425405 MonomethylAuristatinD(MMAD) 203849-91-6 5mg $320 2021-12-16 Buy
Usbiological 456565 Monomethyl Auristatin D 203849-91-6 1mg $333 2021-12-16 Buy
ChemScene CS-1613 MMAD 99.86% 203849-91-6 5mg $80 2021-12-16 Buy
ChemScene CS-1613 MMAD 99.86% 203849-91-6 10mg $140 2021-12-16 Buy
ChemScene CS-1613 MMAD 99.86% 203849-91-6 50mg $450 2021-12-16 Buy
Product number Packaging Price Buy
M425405 5mg $320 Buy
456565 1mg $333 Buy
CS-1613 5mg $80 Buy
CS-1613 10mg $140 Buy
CS-1613 50mg $450 Buy

MonoMethyl Dolastatin 10 Chemical Properties,Uses,Production

Description

Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor. Synonyms: Demethyldolastatin 10; Monomethylauristatin D; MMAD.

Uses

MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.

Biological Activity

mmad is a highly potent inhibitor of tubulin [1].mmad is one of the auristatins, which are used as the drugs of antibody drug conjugates (adcs). in adcs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of mabs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. as a payload of adcs, mmad is used to target the tubulin of the tumor cells. it can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1].additionally, mmad is reported to be used in the production of site-specific antibody drug conjugates (ndcs). in the ndcs, mmad is combined with anti-5t4 antibody or anti-her2 antibody. it is shown that the ndcs demonstrate better efficacy and pharmacokinetics [2].

target

tubulin

References

[1] puja sapra, andrea t hooper, christopher j, o’donnell & hans-peter gerber. investigational antibody drug conjugates for solid tumors. expert opin. investig. drugs. 2011, 20(8):1131-1149.
[2] feng tiana, yingchun lu, anthony manibusan, aaron sellers et al. a general approach to site-specific antibody drug conjugates. pnas. 2014, february, 111(5): 1766-1771.

MonoMethyl Dolastatin 10 Preparation Products And Raw materials

Raw materials

Preparation Products

MonoMethyl Dolastatin 10 Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd 		+86-15542445688 sales@alabiochem.com China 888 58
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29826 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
Zhuoer Chemical Co., Ltd 		02120970332; +8613524231522 sales@zhuoerchem.com China 3005 58
ChemExpress 		+86-021-58950125 info@chemexpress.com China 599 58
Supplier Advantage
Alpha Biopharmaceuticals Co., Ltd 		58
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
career henan chemical co 		58
Hubei Ipure Biology Co., Ltd 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Zhuoer Chemical Co., Ltd 		58
ChemExpress 		58

View Lastest Price from MonoMethyl Dolastatin 10 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MMAD;MonoMethyl Dolastatin 10 pictures 2021-07-13 MMAD;MonoMethyl Dolastatin 10
203849-91-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
MonoMethyl Dolastatin 10 pictures 2020-02-14 MonoMethyl Dolastatin 10
203849-91-6
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co

203849-91-6(MonoMethyl Dolastatin 10)Related Search:

VcMMAD MonoMethylauristatin F McMMAE MC-MMAF McMMAD
N-Methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide DeMethyldolastatin 10 MMAD MonoMethyl Dolastatin 10 MonoMethylauristatin D (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide CS-1368 DEMETHYLDOLASTATIN 10; MONOMETHYLAURISTATIN D; MONOMETHYL DOLASTATIN 10 EOS-60620 MMAD (Demethyldolastatin 10 Demethyldolastatin (MMAD) L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- Thiazole,2-bromo-7-(bromomethyl)- (S)-2-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-N-(methyl-L-valyl)butanamide MonoMethyl Dolastatin 10 / MMAD MMAD MonoMethyl Dolastatin 10 203849-91-6 C41H66N6O6S ADCs