Flumatinib
- CAS No.
- 895519-90-1
- Chemical Name:
- Flumatinib
- Synonyms
- HHGV678;FluMatinib;FLUMATINIB (HHGV678);Flumatinib, 10 mM in DMSO;HHGV-678,Inhibitor,Flumatinib,Bcr-Abl,inhibit,Platelet-derived growth factor receptor,PDGFR,CD117,SCFR,HHGV 678,c-Kit;4-[(4-Methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-
- CBNumber:
- CB22666871
- Molecular Formula:
- C29H29F3N8O
- Molecular Weight:
- 562.59
- MDL Number:
- MFCD18633213
- MOL File:
- 895519-90-1.mol
| Density | 1.340±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);177.75(Max Conc. mM) |
| form | A solid |
| pka | 11.84±0.70(Predicted) |
| color | Off-white to yellow |
| FDA UNII | R4009Y24AI |
Flumatinib price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5550 | Flumatinib 99.94% | 895519-90-1 | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-5550 | Flumatinib 99.94% | 895519-90-1 | 10mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-5550 | Flumatinib 99.94% | 895519-90-1 | 50mg | $228 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026221 | FLUMATINIB 95.00% | 895519-90-1 | 5MG | $504.6 | 2021-12-16 | Buy |
| DC Chemicals | DC11413 | Flumatinib >98% | 895519-90-1 | 1g | $950 | 2021-12-16 | Buy |
Flumatinib Chemical Properties,Uses,Production
Uses
Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[3] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320
[4] Gong A, et al. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metab Dispos. 2010 Aug;38(8):1328-40. DOI:10.1124/dmd.110.032326
Flumatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Flumatinib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Anqing CHICO Pharmaceutical Co., Ltd. | 13585175604 | sales@chicopharm.com | China | 498 | 65 |
View Lastest Price from Flumatinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Flumatinib
895519-90-1
|
US $30.00-79.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. |
-
- Flumatinib
895519-90-1
- US $30.00-79.00 / mg
- 99.95%
- TargetMol Chemicals Inc.