GSK J5
- CAS No.
- 1394854-51-3
- Chemical Name:
- GSK J5
- Synonyms
- GSK-J5;GSK J5;CS-2752;GSK-J5|||GSKJ5;Ethyl N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3- Yl)-4-pyrimidinyl]-β-alaninate;N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester;β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester;N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester
- CBNumber:
- CB22668284
- Molecular Formula:
- C24H27N5O2
- Molecular Weight:
- 417.50348
- MDL Number:
- MFCD27991275
- MOL File:
- 1394854-51-3.mol
- MSDS File:
- SDS
GSK J5 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G797560 | GSKJ5 | 1394854-51-3 | 10mg | $205 | 2021-12-16 | Buy |
| ApexBio Technology | A8792 | GSKJ5HCl | 1394854-51-3 | 5mg | $146 | 2021-12-16 | Buy |
| Chemenu | CM161409 | ethyl3-((2-(pyridin-3-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate 95% | 1394854-51-3 | 10mg | $611 | 2021-12-16 | Buy |
| Crysdot | CD11265845 | GSKJ5 95+% | 1394854-51-3 | 10mg | $654 | 2021-12-16 | Buy |
| Crysdot | CD11265845 | GSKJ5 95+% | 1394854-51-3 | 50mg | $1962 | 2021-12-16 | Buy |
GSK J5 Chemical Properties,Uses,Production
Uses
GSK J5 is a inactive isomer of GSK J4 (G797555), which is a cell permeable inhibitor of the histone demethylase JMJD3/UTX.
Biological Activity
gsk j5 is an inactive isomer of gsk j4 and a cell-permeable ester derivative of inactive control gsk j2. lysine-specific demethylase 6b (kdm6b), also known as jumonji domain-containing protein d3 (jmjd3), was overexpressed in patients with aml and these patients have a poor prognosis. kdm6b-specific pharmacological inhibitor gsk-j4 had a significant anti-proliferative effect in aml cell lines and freshly isolated bm monocytes (mncs) from aml patients, while h3k27me3 levels were also increasing. gsk-j4 also caused apoptosis and cell cycle arrest in vitro, and reduced tumor burden in vivo in aml xenograft mouse models. it is worth noting that injection of gsk-j4 attenuated disease progression in a human aml xenograft mouse model. treatment with gsk-j4 mainly resulted in downregulation of dna replication and cell cycle-related pathways, and prevents the expression of hox, a key cancer gene. chip-qpcr verified the increased h3k27me3 enrichment in the hox gene transcription initiation site [1].[1]. li y, zhang m, sheng m, zhang p, chen z, xing w, bai j, cheng t, yang fc, zhou y. therapeutic potential of gsk-j4, a histone demethylase kdm6b/jmjd3 inhibitor, for acute myeloid leukemia. j cancer res clin oncol. 2018 jun;144(6):1065-1077. doi: 10.1007/s00432-018-2631-7. epub 2018 mar 28. pubmed pmid: 29594337; pubmed central pmcid: pmc5948279.
GSK J5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| RuiErKang Pharmaceuticals, Inc. | 2921645477 | 2921645477@qq.com | China | 132 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6756 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4287 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10520 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |