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K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 Structure
K-Ras(G12C) inhibitor 6 structure
CAS No.
2060530-16-5
Chemical Name:
K-Ras(G12C) inhibitor 6
Synonyms
CS-2013;MDK30165;K-Ras(G12C) inhibitor 6;K-Ras(G12C) inhibitor 6 USP/EP/BP;N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide;Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-;N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide;Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
CBNumber:
CB22728650
Molecular Formula:
C17H22Cl2N2O3S
Molecular Weight:
405.34
MDL Number:
MFCD28099807
MOL File:
2060530-16-5.mol
Last updated:2024-11-01 18:44:47
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K-Ras(G12C) inhibitor 6 Properties

Boiling point 643.4±55.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO
form solid
pka 10.21±0.10(Predicted)
FDA UNII JPV55C3PN4

K-Ras(G12C) inhibitor 6 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D438295 N-​[1-​[2-​(2,​4-Dichlorophenoxy)​acetyl]​-​4-​piperidinyl]​-​4-​mercapto-butanamide 2060530-16-5 10mg $470 2021-12-16 Buy
Biorbyt Ltd orb181272 K-Ras(G12C) inhibitor 6 >98% 2060530-16-5 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb181272 K-Ras(G12C) inhibitor 6 >98% 2060530-16-5 250mg $1431.4 2021-12-16 Buy
Biorbyt Ltd orb181272 K-Ras(G12C) inhibitor 6 >98% 2060530-16-5 1000mg $2691.1 2021-12-16 Buy
ApexBio Technology B3694 K-Ras(G12C)inhibitor6 2060530-16-5 10mM(in 1mL DMSO) $130 2021-12-16 Buy
Product number Packaging Price Buy
D438295 10mg $470 Buy
orb181272 100mg $765 Buy
orb181272 250mg $1431.4 Buy
orb181272 1000mg $2691.1 Buy
B3694 10mM(in 1mL DMSO) $130 Buy

K-Ras(G12C) inhibitor 6 Chemical Properties,Uses,Production

Uses

N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide is an irreversible and allosteric inhibitor of the K-Ras(G12C) mutant. This compound has potential therapeutic application for diseases related to Ras signaling.

Biological Activity

k-ras (g12c) inhibitor 6 is an allosterical inhibitor of oncogenic mutation k-ras g12c [1].k-ras (g12c) inhibitor 6 is a cysteine-reactive small molecule. it irreversibly binds to the g12c mutantion of gtpase k-ras but not the wild-type k-ras with the relative potency value of 4.2. the binding pocket of k-ras for k-ras (g12c) inhibitor 6 is a new allosteric pocket, s-iip. binding of this pocket results in a change of the relative nucleotide affinity of ras to favour gdp over gtp, leading to an accumulation of inactive ras. since the mutation of k-ras is quite common in human cancers, the inhibitor of k-ras g12c should exert suppression activities in tumor cells. it has been reported that, some of the k-ras g12c inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].

References

[1] ostrem j m, peters u, sos m l, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions. nature, 2013, 503(7477): 548-551.

K-Ras(G12C) inhibitor 6 Preparation Products And Raw materials

Raw materials

Preparation Products

K-Ras(G12C) inhibitor 6 Suppliers

Global( 61)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29814 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 23125 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38465 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Boyle Chemical Co., Ltd. 55
AdooQ BioScience, LLC 58

View Lastest Price from K-Ras(G12C) inhibitor 6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
K-Ras(G12C) Inhibitor 6 pictures 2024-11-01 K-Ras(G12C) Inhibitor 6
2060530-16-5
 US $34.00-79.00 / mg 97.01% 10g TargetMol Chemicals Inc.
K-Ras(G12C) inhibitor 6 pictures 2019-12-26 K-Ras(G12C) inhibitor 6
2060530-16-5
 US $1.00 / g 1g 99% 200kg Career Henan Chemical Co

K-Ras(G12C) inhibitor 6 Spectrum

K-Ras(G12C) inhibitor 6(2060530-16-5)1HNMR

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K-Ras(G12C) inhibitor 6 Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto- K-Ras(G12C) inhibitor 6 USP/EP/BP N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide CS-2013 MDK30165 Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6 2060530-16-5 Inhibitors API