ZK200775 (hydrate)
- CAS No.
- 1255517-78-2
- Chemical Name:
- ZK200775 (hydrate)
- Synonyms
- MPQX hydrate;Fanapanel hydrate;ZK200775 (hydrate)
- CBNumber:
- CB22735546
- Molecular Formula:
- C14H17F3N3O7P
- Molecular Weight:
- 427.27
- MDL Number:
- MFCD18452859
- MOL File:
- 1255517-78-2.mol
ZK200775 (hydrate) price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | Z4777 | ZK 200775 hydrate ≥98% (HPLC), powder | 1255517-78-2 | 10mg | $247 | 2024-03-01 | Buy |
Sigma-Aldrich | Z4777 | ZK 200775 hydrate ≥98% (HPLC), powder | 1255517-78-2 | 50mg | $829 | 2024-03-01 | Buy |
ChemScene | CS-3612 | Fanapanelhydrate 99.66% | 1255517-78-2 | 50mg | $710 | 2021-12-16 | Buy |
ChemScene | CS-3612 | Fanapanelhydrate 99.66% | 1255517-78-2 | 10mg | $168 | 2021-12-16 | Buy |
Crysdot | CD31004082 | ZK 200775 hydrate 98+% | 1255517-78-2 | 10mg | $97 | 2021-12-16 | Buy |
ZK200775 (hydrate) Chemical Properties,Uses,Production
Biological Activity
Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA antagonist.
in vitro
In the cortical slice preparation assay, ZK200775 (hydrate) gave Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. In the spreading depression assay, it gave IC50 values of 200 nM , 76 nM, 13 μM, and 18 μM against quisqualate, kainate, NMDA, and glycine [1].
in vivo
ZK200775 (hydrate) elevated the threshold for AMPA- and kainate-induced clonic seizures in mice with a THRD50 (threshold dose) of 2.9 (1.7–4.6) and 1.6 (1.3–2.0) mg/kg iv, whereas the threshold for NMDA-induced seizures was elevated only in doses, THRD50 of 24.1 (21.9–26.5) mg/kg iv, which affected motor coordination in the rotating rod, ED50 14.6 (12.1–17.6) mg/kg. It in doses of 10 and 30 mg/kg iv reduced muscle tone in genetically spastic rats [1]. It (3.0 but not 1.5 or 6.0 mg/kg) significantly decreased the nicotine-induced (0.6 mg/kg) DA release in the NAcc and nicotine-stimulated LMA . It (1.5, 3.0, 6.0 mg/kg) alone influenced neither DA release nor LMA. It showed 34-fold selectivity for AMPA receptors compared to NMDA receptors and no affinity to nicotine receptors [2].
target
AMPAR
ZK200775 (hydrate) Preparation Products And Raw materials
Raw materials
Preparation Products
ZK200775 (hydrate) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |