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ChemicalBook >> CAS DataBase List >>[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone Structure
[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone structure
CAS No.
909418-68-4
Chemical Name:
[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone
Synonyms
GSK575594A;GSK-575594A (GSK575594A);[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone;Methanone, [4-(4-amino-2-fluorophenyl)-1-piperazinyl][4'-fluoro-4-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-;1-(4-Amino-2-fluorophenyl)-4-[[4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]carbonyl]-piperazine (9CI)
CBNumber:
CB22751049
Molecular Formula:
C24H23F2N3O3S
Molecular Weight:
471.52
MDL Number:
MFCD28580121
MOL File:
909418-68-4.mol
Last updated:2025-04-18 09:51:55
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[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone Properties

storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
form powder
color white to beige
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0262 GSK575594A ≥98% (HPLC) 909418-68-4 25mg $538 2024-03-01 Buy
Sigma-Aldrich SML0262 GSK575594A ≥98% (HPLC) 909418-68-4 5mg $113 2022-05-15 Buy
Product number Packaging Price Buy
SML0262 25mg $538 Buy
SML0262 5mg $113 Buy

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone Chemical Properties,Uses,Production

Uses

GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies[1].

Biological Activity

GSK575594A is a selective agonist of human GPR55. It is specific for human over rodent GPR55. GSK575594A had no activity across a set of more than 200 validated molecular target assays from diverse classes including kinases, proteases and other enzymes, GPCRs, ion channels, nuclear receptors, and membrane transporters.

References

[1] Stevanovic S, et al. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Mol Biochem Parasitol. 2021 Mar;242:111350. DOI:10.1016/j.molbiopara.2021.111350

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone Preparation Products And Raw materials

Raw materials

Preparation Products

[4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32239 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19897 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1248 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19820 58
Merck KGaA 21-20338288 ordercn@merckgroup.com China 292394 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 233051 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Merck KGaA 58
Biosynth Biological Technology (Suzhou) Co Ltd 58

View Lastest Price from [4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK575594A pictures 2024-10-24 GSK575594A
909418-68-4
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
  • GSK575594A pictures
  • GSK575594A
    909418-68-4
  • US $1520.00-2500.00 / mg
  • TargetMol Chemicals Inc.
GSK575594A [4-(4-Amino-2-fluorophenyl)-1-piperazinyl][4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]-methanone 1-(4-Amino-2-fluorophenyl)-4-[[4′-fluoro-4-(methylsulfonyl)[1,1′-biphenyl]-2-yl]carbonyl]-piperazine (9CI) GSK-575594A (GSK575594A) Methanone, [4-(4-amino-2-fluorophenyl)-1-piperazinyl][4'-fluoro-4-(methylsulfonyl)[1,1'-biphenyl]-2-yl]- 909418-68-4