ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR
- CAS No.
- Chemical Name:
- ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR
- Synonyms
- Anti-FGFR-2;ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR;Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit;Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit
- CBNumber:
- CB2281311
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02096345
- MOL File:
- Mol file
ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F6796 | Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 0.2mL | $665 | 2024-03-01 | Buy | |
Sigma-Aldrich | F0300 | Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 0.5ml | $419.4 | 2024-03-01 | Buy |
ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Chemical Properties,Uses,Production
Uses
Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit has been used in immunoprecipitation and immunoblotting.
General Description
Fibroblast growth factors receptors (FGFRs) are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110-150 k Da proteins that are constructed of an extracellular ligand binding region with either two or typically three immunoglobulin (Ig)-like domains and an eight amino acid ′acidic box′, a transmembrane region and a cytoplasmic split tyrosine kinase domain that is activated following ligand binding and receptor dimerization. At the mRNA level, FGFR-2 is highly expressed in developing human tissues including the brain (preferentially in glial cells), choroid plexus, skin, lung, kidney and bone. It is widely expressed in many adult human and animal tissues. It may be found in several anchorage-dependent cells, such as normal and malignant breast cancer cells.
Biochem/physiol Actions
Fibroblast growth factors (FGFs) are potent physiological regulators normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, in hematopoiesis as well as in tissue remodeling and maintenance. FGFRs exhibit overlapping recognition and redundant specificity. Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signaling molecules leads to DNA synthesis or differentiation. The signaling and biological responses elicited by distinct FGFRs substantially differ. FGFR-2 is highly expressed in developing human tissues including the brain (preferentially in glial cells), choroid plexus, skin, lung, kidney and bone. It may be found in several anchorage-dependent cells, such as normal and malignant breast cancer cells.
ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Suppliers
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