ChemicalBook >> CAS DataBase List >>6-HYDROXYDOPAMINE HYDROBROMIDE
6-HYDROXYDOPAMINE HYDROBROMIDE
- CAS No.
- 636-00-0
- Chemical Name:
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- Synonyms
- Oxidopamine HBr;6-HYDROXYDOPAMINE HBR;6-OHDA (hydrobromide);6-Hydroxydopamine hydrbromide;2,4,5-Trihydroxyphenethylamine;6-HYDROXYDOPAMINE HYDROBROMIDE;KEMPTIDE, SYNTHETIC, >97% PURITY;Oxidopamine (6-OHDA) hydrobromide;2,5-DIHYDROXYTYRAMINE HYDROBROMIDE;6-HYDROXYDOPAMINE HYDROBROMIDE 99%
- CBNumber:
- CB2288961
- Molecular Formula:
- C8H12BrNO3
- Molecular Weight:
- 250.09
- MDL Number:
- MFCD00012894
- MOL File:
- 636-00-0.mol
- MSDS File:
- SDS
Last updated:2024-11-19 23:02:33
| Melting point | 216-220 °C(lit.) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | solid |
| color | tan to brown |
| BRN | 3713280 |
| Stability | Hygroscopic, Light Sensitive |
| InChIKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| CAS DataBase Reference | 636-00-0(CAS DataBase Reference) |
| FDA UNII | TWC1D4W0WB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DC4600000 | |||||||||
| F | 3-10 | |||||||||
| NFPA 704 |
|
6-HYDROXYDOPAMINE HYDROBROMIDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 162957 | 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | 1g | $479 | 2024-03-01 | Buy |
| Sigma-Aldrich | 162957 | 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | 5g | $1146 | 2024-03-01 | Buy |
| Cayman Chemical | 25330 | 6-OHDA (hydrobromide) ≥95% | 636-00-0 | 50mg | $37 | 2024-03-01 | Buy |
| Sigma-Aldrich | 162957 | 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | 50mg | $41.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 162957 | 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | 250mg | $147 | 2024-03-01 | Buy |
6-HYDROXYDOPAMINE HYDROBROMIDE Chemical Properties,Uses,Production
Description
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.
Chemical Properties
beige to brown crystalline powder
Uses
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
General Description
Solutions should be freshly prepared and protected from exposure to light.
Biochem/physiol Actions
Neurotoxin that destroys catecholaminergic terminals.
storage
-20°C
6-HYDROXYDOPAMINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 141)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5856 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from 6-HYDROXYDOPAMINE HYDROBROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Oxidopamine hydrobromide
636-00-0
|
US $171.00-56.00 / mg | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Oxidopamine hydrobromide
636-00-0
|
US $171.00-56.00 / mg | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-28 | 6-HYDROXYDOPAMINE HYDROBROMIDE
636-00-0
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd |
-
- Oxidopamine hydrobromide
636-00-0
- US $171.00-56.00 / mg
- 99.88%
- TargetMol Chemicals Inc.
-
- Oxidopamine hydrobromide
636-00-0
- US $171.00-56.00 / mg
- 99.88%
- TargetMol Chemicals Inc.
-
- 6-HYDROXYDOPAMINE HYDROBROMIDE
636-00-0
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
636-00-0(6-HYDROXYDOPAMINE HYDROBROMIDE)Related Search:
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6-HYDROXYDOPAMINE HYDROBROMIDE, CRYSTALL IZED
6-Hydroxydopamine hydrobromide,2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
KEMPTIDE, SYNTHETIC, >97% PURITY
6-Hydroxydopaminehydrobromide/ascorbicacid
5-(2-aMinoethyl)benzene-1,2,4-triol hydrobroMide
Oxidopamine HBr
6-Hydroxydopamine hydrobromide contains ascorbic acid as stabilizer, >=98% (HPLC)
6-OHDA (hydrobromide)
6-HYDROXYDOPAMINE HYDROBROMIDE USP/EP/BP
6-OHDA HBr (Oxidopamine hydrobromide)
neurotoxicity,Autophagy,Interleukin Related,Parkinson’s disease,6-Hydroxydopamine,Oxidopamine hydrobromide,Caspase,6-OHDA,Lesch-Nyhan syndrome,PC12 cells,p38 MAPK,Mitophagy,inhibit,Inhibitor,Mitochondrial Autophagy,p-p38,COX,Prostaglandin E synthase,attention-deficit hyperactivity disorder,PGE2,Dopamine Receptor,SH-SY5Y cells,Apoptosis,Oxidopamine,Neuro-2a cells,Cyclooxygenase,PGE synthase
Oxidopamine (6-OHDA) hydrobromide
636-00-0
HO3C6H2CH2CH2NH2HBr
C8H11N1O3
C8H12NO3Br
C8H11NO3HBr
C8H11NO3BrH
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